Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers
All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/7/1/13 |
| _version_ | 1797396274591301632 |
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| author | Carlos García-Padilla Estefanía Lozano-Velasco Carmen López-Sánchez Virginio Garcia-Martínez Amelia Aranega Diego Franco |
| author_facet | Carlos García-Padilla Estefanía Lozano-Velasco Carmen López-Sánchez Virginio Garcia-Martínez Amelia Aranega Diego Franco |
| author_sort | Carlos García-Padilla |
| collection | DOAJ |
| description | All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. |
| first_indexed | 2024-03-09T00:48:58Z |
| format | Article |
| id | doaj.art-ceaed36d91304b12ab3a351c58a60e5e |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-09T00:48:58Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-ceaed36d91304b12ab3a351c58a60e5e2023-12-11T17:21:32ZengMDPI AGNon-Coding RNA2311-553X2021-02-01711310.3390/ncrna7010013Non-Coding RNAs in Retinoic Acid as Differentiation and Disease DriversCarlos García-Padilla0Estefanía Lozano-Velasco1Carmen López-Sánchez2Virginio Garcia-Martínez3Amelia Aranega4Diego Franco5Department of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Human Anatomy and Embryology, University of Extremadura, 06006 Badajoz, SpainDepartment of Human Anatomy and Embryology, University of Extremadura, 06006 Badajoz, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainDepartment of Experimental Biology, University of Jaen, 23071 Jaen, SpainAll-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease.https://www.mdpi.com/2311-553X/7/1/13retinoic acidmicroRNAslncRNAsdevelopmentdisease |
| spellingShingle | Carlos García-Padilla Estefanía Lozano-Velasco Carmen López-Sánchez Virginio Garcia-Martínez Amelia Aranega Diego Franco Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers Non-Coding RNA retinoic acid microRNAs lncRNAs development disease |
| title | Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers |
| title_full | Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers |
| title_fullStr | Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers |
| title_full_unstemmed | Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers |
| title_short | Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers |
| title_sort | non coding rnas in retinoic acid as differentiation and disease drivers |
| topic | retinoic acid microRNAs lncRNAs development disease |
| url | https://www.mdpi.com/2311-553X/7/1/13 |
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