Human Polyomavirus 9 Infection in Kidney Transplant Patients
Several human polyomaviruses of unknown prevalence and pathogenicity have been identified, including human polyomavirus 9 (HPyV9). To determine rates of HPyV9 infection among immunosuppressed patients, we screened serum samples from 101 kidney transplant patients in the Netherlands for HPyV9 DNA and...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2014-06-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/20/6/14-0055_article |
| _version_ | 1818246517880782848 |
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| author | Els van der Meijden Herman F. Wunderink Caroline S. van der Blij-de Brouwer Hans L. Zaaijer Joris I. Rotmans Jan Nico Bouwes Bavinck Mariet C.W. Feltkamp |
| author_facet | Els van der Meijden Herman F. Wunderink Caroline S. van der Blij-de Brouwer Hans L. Zaaijer Joris I. Rotmans Jan Nico Bouwes Bavinck Mariet C.W. Feltkamp |
| author_sort | Els van der Meijden |
| collection | DOAJ |
| description | Several human polyomaviruses of unknown prevalence and pathogenicity have been identified, including human polyomavirus 9 (HPyV9). To determine rates of HPyV9 infection among immunosuppressed patients, we screened serum samples from 101 kidney transplant patients in the Netherlands for HPyV9 DNA and seroreactivity. A total of 21 patients had positive results for HPyV9 DNA; positivity rates peaked at 3 months after transplantation, but the highest viral loads were measured just after transplantation. During 18 months of follow-up, HPyV9 seroprevalence increased from 33% to 46% among transplant patients; seroprevalence remained stable at ≈30% in a control group of healthy blood donors in whom no HPyV9 DNA was detected. Further analysis revealed an association between detection of HPyV9 and detection of BK polyomavirus but not of cytomegalovirus. Our data indicate that HPyV9 infection is frequent in kidney transplant patients, but the nature of infection—endogenous or donor-derived—and pathogenic potential of this virus remain unknown. |
| first_indexed | 2024-12-12T14:50:04Z |
| format | Article |
| id | doaj.art-ceaefcaa7302458587a7e6e3ae8a2d8c |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-12T14:50:04Z |
| publishDate | 2014-06-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-ceaefcaa7302458587a7e6e3ae8a2d8c2022-12-22T00:21:01ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592014-06-0120699199910.3201/eid2006.140055Human Polyomavirus 9 Infection in Kidney Transplant PatientsEls van der MeijdenHerman F. WunderinkCaroline S. van der Blij-de BrouwerHans L. ZaaijerJoris I. RotmansJan Nico Bouwes BavinckMariet C.W. FeltkampSeveral human polyomaviruses of unknown prevalence and pathogenicity have been identified, including human polyomavirus 9 (HPyV9). To determine rates of HPyV9 infection among immunosuppressed patients, we screened serum samples from 101 kidney transplant patients in the Netherlands for HPyV9 DNA and seroreactivity. A total of 21 patients had positive results for HPyV9 DNA; positivity rates peaked at 3 months after transplantation, but the highest viral loads were measured just after transplantation. During 18 months of follow-up, HPyV9 seroprevalence increased from 33% to 46% among transplant patients; seroprevalence remained stable at ≈30% in a control group of healthy blood donors in whom no HPyV9 DNA was detected. Further analysis revealed an association between detection of HPyV9 and detection of BK polyomavirus but not of cytomegalovirus. Our data indicate that HPyV9 infection is frequent in kidney transplant patients, but the nature of infection—endogenous or donor-derived—and pathogenic potential of this virus remain unknown.https://wwwnc.cdc.gov/eid/article/20/6/14-0055_articlepolyomavirusHPyV9BKPyVimmunocompromized hostkidney transplantationkidney transplant |
| spellingShingle | Els van der Meijden Herman F. Wunderink Caroline S. van der Blij-de Brouwer Hans L. Zaaijer Joris I. Rotmans Jan Nico Bouwes Bavinck Mariet C.W. Feltkamp Human Polyomavirus 9 Infection in Kidney Transplant Patients Emerging Infectious Diseases polyomavirus HPyV9 BKPyV immunocompromized host kidney transplantation kidney transplant |
| title | Human Polyomavirus 9 Infection in Kidney Transplant Patients |
| title_full | Human Polyomavirus 9 Infection in Kidney Transplant Patients |
| title_fullStr | Human Polyomavirus 9 Infection in Kidney Transplant Patients |
| title_full_unstemmed | Human Polyomavirus 9 Infection in Kidney Transplant Patients |
| title_short | Human Polyomavirus 9 Infection in Kidney Transplant Patients |
| title_sort | human polyomavirus 9 infection in kidney transplant patients |
| topic | polyomavirus HPyV9 BKPyV immunocompromized host kidney transplantation kidney transplant |
| url | https://wwwnc.cdc.gov/eid/article/20/6/14-0055_article |
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