Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation
Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 µg/kg body weight (low dose) of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/10/5/224 |
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| author | Sabina Šturm Klaus Weber Primož Klinc Ellinor Spörndly-Nees Azadeh Fakhrzadeh Tanja Knific Andrej Škibin Věra Fialová Yoshimasa Okazaki Tanja Razinger Jürgen Laufs Robert Kreutzer Milan Pogačnik Tanja Švara Vesna Cerkvenik-Flajs |
| author_facet | Sabina Šturm Klaus Weber Primož Klinc Ellinor Spörndly-Nees Azadeh Fakhrzadeh Tanja Knific Andrej Škibin Věra Fialová Yoshimasa Okazaki Tanja Razinger Jürgen Laufs Robert Kreutzer Milan Pogačnik Tanja Švara Vesna Cerkvenik-Flajs |
| author_sort | Sabina Šturm |
| collection | DOAJ |
| description | Bisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 µg/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and epididymides, and sperm analyses, and compared these parameters between the group of treated rams and the control group of rams. Although there were some differences between the two groups, these differences were not large or statistically significant. The only statistically significant difference was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined after the first administration, and the toxicokinetic parameters of total BPA were calculated. In this study, no major signs of altered reproduction in rams were detected. |
| first_indexed | 2024-03-10T01:42:40Z |
| format | Article |
| id | doaj.art-ceaf54fb99a4499db88b2a5d7b4d0bb5 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-10T01:42:40Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-ceaf54fb99a4499db88b2a5d7b4d0bb52023-11-23T13:21:26ZengMDPI AGToxics2305-63042022-04-0110522410.3390/toxics10050224Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity InvestigationSabina Šturm0Klaus Weber1Primož Klinc2Ellinor Spörndly-Nees3Azadeh Fakhrzadeh4Tanja Knific5Andrej Škibin6Věra Fialová7Yoshimasa Okazaki8Tanja Razinger9Jürgen Laufs10Robert Kreutzer11Milan Pogačnik12Tanja Švara13Vesna Cerkvenik-Flajs14Veterinary Faculty, University of Ljubljana, Gerbičeva Ulica 60, 1000 Ljubljana, SloveniaAnaPath Services GmbH, Hammerstrasse 49, 4410 Liestal, SwitzerlandVeterinary Faculty, University of Ljubljana, Gerbičeva Ulica 60, 1000 Ljubljana, SloveniaDepartment of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, P.O. Box 7011, 75007 Uppsala, SwedenIranian Research Institute for Information Science and Technology (IranDoc) Tehran Province, No. 1090, Enghelab, Tehran 13157 73314, IranVeterinary Faculty, University of Ljubljana, Gerbičeva Ulica 60, 1000 Ljubljana, SloveniaVeterinary Faculty, University of Ljubljana, Gerbičeva Ulica 60, 1000 Ljubljana, SloveniaBiopharm, Research Institute of Biopharmacy and Veterinary Drugs, Pohoří-Chotouň 90, 254 01 Jílové u Prahy, Czech RepublicAnaPath Services GmbH, Hammerstrasse 49, 4410 Liestal, SwitzerlandAnaPath Services GmbH, Hammerstrasse 49, 4410 Liestal, SwitzerlandAnaPath Services GmbH, Hammerstrasse 49, 4410 Liestal, SwitzerlandAnaPath Services GmbH, Hammerstrasse 49, 4410 Liestal, SwitzerlandVeterinary Faculty, University of Ljubljana, Gerbičeva Ulica 60, 1000 Ljubljana, SloveniaVeterinary Faculty, University of Ljubljana, Gerbičeva Ulica 60, 1000 Ljubljana, SloveniaVeterinary Faculty, University of Ljubljana, Gerbičeva Ulica 60, 1000 Ljubljana, SloveniaBisphenol A (BPA), an endocrine-disrupting chemical and environmental pollutant, has been reported by many researchers to induce male reproductive toxicity in different experimental models. In this study, we investigated whether long-term exposure for two months to 25 µg/kg body weight (low dose) of BPA affects spermatogenesis or sperm quality in young Istrian Pramenka rams exposed via diet. We evaluated body and testicular weights, histopathology of testes and epididymides, and sperm analyses, and compared these parameters between the group of treated rams and the control group of rams. Although there were some differences between the two groups, these differences were not large or statistically significant. The only statistically significant difference was the lower epithelial height of seminiferous tubules in treated rams, compared to control rams. In addition to assessing toxicity, BPA concentrations in the blood plasma of treated rams were determined after the first administration, and the toxicokinetic parameters of total BPA were calculated. In this study, no major signs of altered reproduction in rams were detected.https://www.mdpi.com/2305-6304/10/5/224bisphenol Aramstoxicokineticsmale toxicitysperm |
| spellingShingle | Sabina Šturm Klaus Weber Primož Klinc Ellinor Spörndly-Nees Azadeh Fakhrzadeh Tanja Knific Andrej Škibin Věra Fialová Yoshimasa Okazaki Tanja Razinger Jürgen Laufs Robert Kreutzer Milan Pogačnik Tanja Švara Vesna Cerkvenik-Flajs Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation Toxics bisphenol A rams toxicokinetics male toxicity sperm |
| title | Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation |
| title_full | Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation |
| title_fullStr | Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation |
| title_full_unstemmed | Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation |
| title_short | Basic Exploratory Study of Bisphenol A (BPA) Dietary Administration to Istrian Pramenka Rams and Male Toxicity Investigation |
| title_sort | basic exploratory study of bisphenol a bpa dietary administration to istrian pramenka rams and male toxicity investigation |
| topic | bisphenol A rams toxicokinetics male toxicity sperm |
| url | https://www.mdpi.com/2305-6304/10/5/224 |
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