Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke

Genetic Deletion or Pharmacological Inhibition of Cyclooxygenase-2 Reduces Blood-Brain Barrier Damage in Experimental Ischemic Stroke

Cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-9 are two crucial mediators contributing to blood-brain barrier (BBB) damage during cerebral ischemia. However, it is not known whether MMP-9 activation is involved in COX-2-mediated BBB disruption in ischemic stroke. In this study, we hypoth...

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Bibliographic Details
Main Authors: Changjun Yang, Yi Yang, Kelly M. DeMars, Gary A. Rosenberg, Eduardo Candelario-Jalil
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neurology
Subjects:
ischemic stroke
blood-brain barrier
cyclooxygenase-2
matrix metalloproteinase-9
tight junction proteins
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00887/full

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