Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach?
Pancreatic cancer is a devastating disease. It is the fourth leading cause of cancer-related death in Germany. The incidence in 2003/2004 was 16 cases per 100.000 inhabitants. Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates of 25% and less...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2011-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6694/3/2/2286/ |
| _version_ | 1797763243835392000 |
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| author | Robert Grutzmann Hans Detlev Saeger Christian Pilarsky Daniel Zips Gunnar Folprecht Carolin Zimmermann |
| author_facet | Robert Grutzmann Hans Detlev Saeger Christian Pilarsky Daniel Zips Gunnar Folprecht Carolin Zimmermann |
| author_sort | Robert Grutzmann |
| collection | DOAJ |
| description | Pancreatic cancer is a devastating disease. It is the fourth leading cause of cancer-related death in Germany. The incidence in 2003/2004 was 16 cases per 100.000 inhabitants. Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates of 25% and less than 5%, respectively, regardless of the stage at diagnosis. These low survival rates demonstrate the poor prognosis of this carcinoma. Previous therapeutic approaches including surgical resection combined with adjuvant therapy or palliative chemoradiation have not achieved satisfactory results with respect to overall survival. Therefore, it is necessary to evaluate new therapeutic approaches. Neoadjuvant therapy is an interesting therapeutic option for patients with pancreatic cancer. For selected patients with borderline or unresectable disease, neoadjuvant therapy offers the potential for tumor downstaging, increasing the probability of a margin-negative resection and decreasing the occurrence of lymph node metastasis. Currently, there is no universally accepted approach for treating patients with pancreatic cancer in the neoadjuvant setting. In this review, the most common neoadjuvant strategies will be described, compared and discussed. |
| first_indexed | 2024-03-12T19:38:48Z |
| format | Article |
| id | doaj.art-ceb23674017345c8b3deee73823f9bd0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T19:38:48Z |
| publishDate | 2011-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ceb23674017345c8b3deee73823f9bd02023-08-02T04:00:21ZengMDPI AGCancers2072-66942011-05-01322286230110.3390/cancers3022286Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach?Robert GrutzmannHans Detlev SaegerChristian PilarskyDaniel ZipsGunnar FolprechtCarolin ZimmermannPancreatic cancer is a devastating disease. It is the fourth leading cause of cancer-related death in Germany. The incidence in 2003/2004 was 16 cases per 100.000 inhabitants. Of all carcinomas, pancreatic cancer has the highest mortality rate, with one- and five-year survival rates of 25% and less than 5%, respectively, regardless of the stage at diagnosis. These low survival rates demonstrate the poor prognosis of this carcinoma. Previous therapeutic approaches including surgical resection combined with adjuvant therapy or palliative chemoradiation have not achieved satisfactory results with respect to overall survival. Therefore, it is necessary to evaluate new therapeutic approaches. Neoadjuvant therapy is an interesting therapeutic option for patients with pancreatic cancer. For selected patients with borderline or unresectable disease, neoadjuvant therapy offers the potential for tumor downstaging, increasing the probability of a margin-negative resection and decreasing the occurrence of lymph node metastasis. Currently, there is no universally accepted approach for treating patients with pancreatic cancer in the neoadjuvant setting. In this review, the most common neoadjuvant strategies will be described, compared and discussed.http://www.mdpi.com/2072-6694/3/2/2286/pancreas cancerneoadjuvant therapyadjuvantradiotherapychemotherapy |
| spellingShingle | Robert Grutzmann Hans Detlev Saeger Christian Pilarsky Daniel Zips Gunnar Folprecht Carolin Zimmermann Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach? Cancers pancreas cancer neoadjuvant therapy adjuvant radiotherapy chemotherapy |
| title | Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach? |
| title_full | Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach? |
| title_fullStr | Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach? |
| title_full_unstemmed | Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach? |
| title_short | Neoadjuvant Therapy in Patients with Pancreatic Cancer: A Disappointing Therapeutic Approach? |
| title_sort | neoadjuvant therapy in patients with pancreatic cancer a disappointing therapeutic approach |
| topic | pancreas cancer neoadjuvant therapy adjuvant radiotherapy chemotherapy |
| url | http://www.mdpi.com/2072-6694/3/2/2286/ |
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