On the role of allergen-specific IgG subclasses for blocking human basophil activation

On the role of allergen-specific IgG subclasses for blocking human basophil activation

Successful treatment of IgE mediated allergies by allergen-specific immunotherapy (AIT) usually correlates with the induction of allergen-specific IgG4. However, it is not clear whether IgG4 prevents the allergic reaction more efficiently than other IgG subclasses. Here we aimed to compare allergen-...

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Bibliographic Details
Main Authors: Simon Zinkhan, Franziska Thoms, Gilles Augusto, Monique Vogel, Martin F. Bachmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
allergen-specific immunotherapy
IgG1
IgG4
FcγRIIb
allergen
basophils
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.892631/full

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