Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study.
<h4>Background</h4>Circulating levels of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), are positively associated with the prevalence of metabolic syndrome (MetS) in cross-sectional investigations. It is unclear if circulating ADMA and other methyl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0254577 |
| _version_ | 1798032859662909440 |
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| author | Ibrahim Musa Yola Carlee Moser Meredith S Duncan Edzard Schwedhelm Dorothee Atzler Renke Maas Juliane Hannemann Rainer H Böger Ramachandran S Vasan Vanessa Xanthakis |
| author_facet | Ibrahim Musa Yola Carlee Moser Meredith S Duncan Edzard Schwedhelm Dorothee Atzler Renke Maas Juliane Hannemann Rainer H Böger Ramachandran S Vasan Vanessa Xanthakis |
| author_sort | Ibrahim Musa Yola |
| collection | DOAJ |
| description | <h4>Background</h4>Circulating levels of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), are positively associated with the prevalence of metabolic syndrome (MetS) in cross-sectional investigations. It is unclear if circulating ADMA and other methylarginines are associated with incident MetS prospectively.<h4>Methods</h4>We related circulating ADMA, symmetric dimethylarginine (SDMA), L-arginine (ARG) concentrations (measured with a validated tandem mass spectrometry assay) and the ARG/ADMA ratio to MetS and its components in 2914 (cross-sectional analysis, logistic regression; mean age 58 years, 55% women) and 1656 (prospective analysis, Cox regression; mean age 56 years, 59% women) individuals from the Framingham Offspring Study who attended a routine examination.<h4>Results</h4>Adjusting for age, sex, smoking, and eGFR, we observed significant associations of ADMA (direct) and ARG/ADMA (inverse) with odds of MetS (N = 1461 prevalent cases; Odds Ratio [OR] per SD increment 1.13, 95%CI 1.04-1.22; and 0.89, 95%CI 0.82-0.97 for ADMA and ARG/ADMA, respectively). Upon further adjustment for waist circumference, systolic and diastolic blood pressure, glucose, high-density lipoprotein cholesterol, and triglycerides, we observed a positive relation between SDMA and MetS (OR per SD increment 1.15, 95% CI 1.01-1.30) but the other associations were rendered statistically non-significant. We did not observe statistically significant associations between any of the methylarginines and the risk of new-onset MetS (752 incident events) over a median follow-up of 11 years.<h4>Conclusion</h4>It is unclear whether dimethylarginines play an important role in the incidence of cardiometabolic risk in the community, notwithstanding cross-sectional associations. Further studies of larger samples are needed to replicate our findings. |
| first_indexed | 2024-04-11T20:20:33Z |
| format | Article |
| id | doaj.art-ceb4479eea9640919734a6f24a35e397 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T20:20:33Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ceb4479eea9640919734a6f24a35e3972022-12-22T04:04:49ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01169e025457710.1371/journal.pone.0254577Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study.Ibrahim Musa YolaCarlee MoserMeredith S DuncanEdzard SchwedhelmDorothee AtzlerRenke MaasJuliane HannemannRainer H BögerRamachandran S VasanVanessa Xanthakis<h4>Background</h4>Circulating levels of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), are positively associated with the prevalence of metabolic syndrome (MetS) in cross-sectional investigations. It is unclear if circulating ADMA and other methylarginines are associated with incident MetS prospectively.<h4>Methods</h4>We related circulating ADMA, symmetric dimethylarginine (SDMA), L-arginine (ARG) concentrations (measured with a validated tandem mass spectrometry assay) and the ARG/ADMA ratio to MetS and its components in 2914 (cross-sectional analysis, logistic regression; mean age 58 years, 55% women) and 1656 (prospective analysis, Cox regression; mean age 56 years, 59% women) individuals from the Framingham Offspring Study who attended a routine examination.<h4>Results</h4>Adjusting for age, sex, smoking, and eGFR, we observed significant associations of ADMA (direct) and ARG/ADMA (inverse) with odds of MetS (N = 1461 prevalent cases; Odds Ratio [OR] per SD increment 1.13, 95%CI 1.04-1.22; and 0.89, 95%CI 0.82-0.97 for ADMA and ARG/ADMA, respectively). Upon further adjustment for waist circumference, systolic and diastolic blood pressure, glucose, high-density lipoprotein cholesterol, and triglycerides, we observed a positive relation between SDMA and MetS (OR per SD increment 1.15, 95% CI 1.01-1.30) but the other associations were rendered statistically non-significant. We did not observe statistically significant associations between any of the methylarginines and the risk of new-onset MetS (752 incident events) over a median follow-up of 11 years.<h4>Conclusion</h4>It is unclear whether dimethylarginines play an important role in the incidence of cardiometabolic risk in the community, notwithstanding cross-sectional associations. Further studies of larger samples are needed to replicate our findings.https://doi.org/10.1371/journal.pone.0254577 |
| spellingShingle | Ibrahim Musa Yola Carlee Moser Meredith S Duncan Edzard Schwedhelm Dorothee Atzler Renke Maas Juliane Hannemann Rainer H Böger Ramachandran S Vasan Vanessa Xanthakis Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. PLoS ONE |
| title | Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. |
| title_full | Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. |
| title_fullStr | Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. |
| title_full_unstemmed | Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. |
| title_short | Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. |
| title_sort | associations of circulating dimethylarginines with the metabolic syndrome in the framingham offspring study |
| url | https://doi.org/10.1371/journal.pone.0254577 |
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