Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H2O2-Dependent Manner

Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H2O2-Dependent Manner

Lung cancer, together with head and neck cancer, accounts for more than one-fourth of cancer deaths worldwide. New, non-toxic therapeutic approaches are needed. High-dose IV vitamin C (aka, pharmacological ascorbate; P-AscH−) represents a promising adjuvant to radiochemotherapy that exerts its anti-...

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Bibliographic Details
Main Authors: Collin D. Heer, Andrew B. Davis, David B. Riffe, Brett A. Wagner, Kelly C. Falls, Bryan G. Allen, Garry R. Buettner, Robert A. Beardsley, Dennis P. Riley, Douglas R. Spitz
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Antioxidants
Subjects:
SOD mimetic
pharmacological ascorbate
vitamin C
head and neck cancer
lung cancer
radiation therapy
GC4419
oxidative stress
hydrogen peroxide
Online Access:http://www.mdpi.com/2076-3921/7/1/18

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