Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution
Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic, representing significant drivers of tumourigenes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/9/1376 |
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| author | Cian Glenfield Hideki Innan |
| author_facet | Cian Glenfield Hideki Innan |
| author_sort | Cian Glenfield |
| collection | DOAJ |
| description | Chromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic, representing significant drivers of tumourigenesis and cancer evolution. In certain subsets of cancers duplicated and fused genes appear to be essential for initiation of tumour formation, and some even have the capability of transforming normal cells, highlighting the importance of understanding the events that result in their formation. The mechanisms that drive gene duplication and fusion are unregulated in cancer and they facilitate rapid evolution by selective forces akin to Darwinian survival of the fittest on a cellular level. In this review, we examine current knowledge of the landscape and prevalence of gene duplication and gene fusion in human cancers. |
| first_indexed | 2024-03-10T07:39:03Z |
| format | Article |
| id | doaj.art-ceb789a8ce47443ea0d48438ee8ce330 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T07:39:03Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-ceb789a8ce47443ea0d48438ee8ce3302023-11-22T13:14:07ZengMDPI AGGenes2073-44252021-08-01129137610.3390/genes12091376Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer EvolutionCian Glenfield0Hideki Innan1Department of Evolutionary Studies of Biosystems, SOKENDAI, The Graduate University for Advanced Studies, Shonan Village, Hayama, Kanagawar 240-0193, JapanDepartment of Evolutionary Studies of Biosystems, SOKENDAI, The Graduate University for Advanced Studies, Shonan Village, Hayama, Kanagawar 240-0193, JapanChromosomal rearrangement and genome instability are common features of cancer cells in human. Consequently, gene duplication and gene fusion events are frequently observed in human malignancies and many of the products of these events are pathogenic, representing significant drivers of tumourigenesis and cancer evolution. In certain subsets of cancers duplicated and fused genes appear to be essential for initiation of tumour formation, and some even have the capability of transforming normal cells, highlighting the importance of understanding the events that result in their formation. The mechanisms that drive gene duplication and fusion are unregulated in cancer and they facilitate rapid evolution by selective forces akin to Darwinian survival of the fittest on a cellular level. In this review, we examine current knowledge of the landscape and prevalence of gene duplication and gene fusion in human cancers.https://www.mdpi.com/2073-4425/12/9/1376tumour evolutiongene duplicationgene amplificationgene fusioncancer genomegenome rearrangement |
| spellingShingle | Cian Glenfield Hideki Innan Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution Genes tumour evolution gene duplication gene amplification gene fusion cancer genome genome rearrangement |
| title | Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution |
| title_full | Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution |
| title_fullStr | Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution |
| title_full_unstemmed | Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution |
| title_short | Gene Duplication and Gene Fusion Are Important Drivers of Tumourigenesis during Cancer Evolution |
| title_sort | gene duplication and gene fusion are important drivers of tumourigenesis during cancer evolution |
| topic | tumour evolution gene duplication gene amplification gene fusion cancer genome genome rearrangement |
| url | https://www.mdpi.com/2073-4425/12/9/1376 |
| work_keys_str_mv | AT cianglenfield geneduplicationandgenefusionareimportantdriversoftumourigenesisduringcancerevolution AT hidekiinnan geneduplicationandgenefusionareimportantdriversoftumourigenesisduringcancerevolution |