Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors
Levothyroxine tablet has been used for improving serum thyroid hormones. Despite its efficacy, there has been a persistent recurrence. We aimed to evaluate the efficacy of levothyroxine regimen (administered as sodium tablets or liquid) therapy, including the regime in combination with other thyrox...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2023-09-01
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| Series: | European Journal of Translational Myology |
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| Online Access: | https://www.pagepressjournals.org/index.php/bam/article/view/11582 |
| _version_ | 1797692218044055552 |
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| author | Dingji Hao Linxiao Tian Haoting He Congru Zhu Lili Guo Keao Zhang Jie Zhang |
| author_facet | Dingji Hao Linxiao Tian Haoting He Congru Zhu Lili Guo Keao Zhang Jie Zhang |
| author_sort | Dingji Hao |
| collection | DOAJ |
| description |
Levothyroxine tablet has been used for improving serum thyroid hormones. Despite its efficacy, there has been a persistent recurrence. We aimed to evaluate the efficacy of levothyroxine regimen (administered as sodium tablets or liquid) therapy, including the regime in combination with other thyroxine hormones, to determine its effectiveness and safety regarding thyroid tumor patient outcomes. An electronic search of the online databases (PubMed, EMBASE, and Web of Science) was performed in duplicate independently by two authors (SSK and LPY) to identify any potential studies published in the English language from January 2002 to October 2022. The records were retrieved using keywords and MeSH terms. The Cochrane risk of bias tool in the Review Manager (RevMan software version 5.4.) was used to evaluate the risk of bias in the included studies. A total of 18 quality studies were reported on levothyroxine tablets. Results showed that liquid levothyroxine was more efficient than tablet levothyroxine. Further results showed that levothyroxine in combination with L-T3 or I-131 was more effective than L-T4 tablet monotherapy for improving thyroid cancer hormones. Levothyroxine tablet monotherapy is less efficient than liquid levothyroxine and/or levothyroxine combined therapy. This research recommends future research using larger randomized controlled studies.
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| first_indexed | 2024-03-12T02:24:27Z |
| format | Article |
| id | doaj.art-ceb954d1752043dd93653d8013b7dc8e |
| institution | Directory Open Access Journal |
| issn | 2037-7452 2037-7460 |
| language | English |
| last_indexed | 2024-03-12T02:24:27Z |
| publishDate | 2023-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj.art-ceb954d1752043dd93653d8013b7dc8e2023-09-05T22:57:34ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602023-09-0110.4081/ejtm.2023.11582Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumorsDingji Hao0Linxiao Tian1Haoting He2Congru Zhu3Lili Guo4Keao Zhang5Jie Zhang6Department of Oncology, Tonglu County Hospital of Traditional Chinese Medicine, Tonglu, ZhejiangDepartment of Oncology, Tonglu County Hospital of Traditional Chinese Medicine, Tonglu, ZhejiangDepartment of Oncology, Tonglu County Hospital of Traditional Chinese Medicine, Tonglu, ZhejiangDepartment of Oncology, Tonglu County Hospital of Traditional Chinese Medicine, Tonglu, ZhejiangDepartment of Oncology, Tonglu County Hospital of Traditional Chinese Medicine, Tonglu, ZhejiangDepartment of Oncology, Tonglu County Hospital of Traditional Chinese Medicine, Tonglu, ZhejiangDepartment of Oncology, Tonglu County Hospital of Traditional Chinese Medicine, Tonglu, Zhejiang Levothyroxine tablet has been used for improving serum thyroid hormones. Despite its efficacy, there has been a persistent recurrence. We aimed to evaluate the efficacy of levothyroxine regimen (administered as sodium tablets or liquid) therapy, including the regime in combination with other thyroxine hormones, to determine its effectiveness and safety regarding thyroid tumor patient outcomes. An electronic search of the online databases (PubMed, EMBASE, and Web of Science) was performed in duplicate independently by two authors (SSK and LPY) to identify any potential studies published in the English language from January 2002 to October 2022. The records were retrieved using keywords and MeSH terms. The Cochrane risk of bias tool in the Review Manager (RevMan software version 5.4.) was used to evaluate the risk of bias in the included studies. A total of 18 quality studies were reported on levothyroxine tablets. Results showed that liquid levothyroxine was more efficient than tablet levothyroxine. Further results showed that levothyroxine in combination with L-T3 or I-131 was more effective than L-T4 tablet monotherapy for improving thyroid cancer hormones. Levothyroxine tablet monotherapy is less efficient than liquid levothyroxine and/or levothyroxine combined therapy. This research recommends future research using larger randomized controlled studies. https://www.pagepressjournals.org/index.php/bam/article/view/11582Levothyroxinelevothyroxine liquidiodine (I-131)levo-thyronine (L-T4)thyroxine serum hormonethyroid cancer |
| spellingShingle | Dingji Hao Linxiao Tian Haoting He Congru Zhu Lili Guo Keao Zhang Jie Zhang Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors European Journal of Translational Myology Levothyroxine levothyroxine liquid iodine (I-131) levo-thyronine (L-T4) thyroxine serum hormone thyroid cancer |
| title | Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors |
| title_full | Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors |
| title_fullStr | Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors |
| title_full_unstemmed | Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors |
| title_short | Efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors |
| title_sort | efficacy and safety of postoperative levothyroxine sodium tablets for improving serum thyroid hormone levels and tumor marker levels in patients with thyroid tumors |
| topic | Levothyroxine levothyroxine liquid iodine (I-131) levo-thyronine (L-T4) thyroxine serum hormone thyroid cancer |
| url | https://www.pagepressjournals.org/index.php/bam/article/view/11582 |
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