The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease
Background: Although magnetic resonance imaging (MRI) of the membranous labyrinth and electrocochleography (ECochG) have been used to diagnose endolymphatic hydrops (ELH) in patients with Ménière's disease (MD), the relationship between imaging and ECochG is not well-documented.Objectives: This...
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Frontiers Media S.A.
2021-01-01
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| author | Baihui He Baihui He Baihui He Fan Zhang Fan Zhang Fan Zhang Hui Zheng Xiayu Sun Xiayu Sun Xiayu Sun Junmin Chen Junmin Chen Junmin Chen Jianyong Chen Jianyong Chen Jianyong Chen Yupeng Liu Yupeng Liu Yupeng Liu Lu Wang Lu Wang Lu Wang Wei Wang Wei Wang Wei Wang Shuna Li Shuna Li Shuna Li Jun Yang Jun Yang Jun Yang Maoli Duan Maoli Duan |
| author_facet | Baihui He Baihui He Baihui He Fan Zhang Fan Zhang Fan Zhang Hui Zheng Xiayu Sun Xiayu Sun Xiayu Sun Junmin Chen Junmin Chen Junmin Chen Jianyong Chen Jianyong Chen Jianyong Chen Yupeng Liu Yupeng Liu Yupeng Liu Lu Wang Lu Wang Lu Wang Wei Wang Wei Wang Wei Wang Shuna Li Shuna Li Shuna Li Jun Yang Jun Yang Jun Yang Maoli Duan Maoli Duan |
| author_sort | Baihui He |
| collection | DOAJ |
| description | Background: Although magnetic resonance imaging (MRI) of the membranous labyrinth and electrocochleography (ECochG) have been used to diagnose endolymphatic hydrops (ELH) in patients with Ménière's disease (MD), the relationship between imaging and ECochG is not well-documented.Objectives: This study evaluates the ELH using 3D-FLAIR MRI and extra-tympanic ECochG (ET-ECochG) and correlates the results from 3D-FLAIR MRI to those from ET-ECochG.Materials and Methods: 3D-FLAIR MRI images of 50 patients were assessed using a 2D volume-referencing grading system (VR scores, relative scores according to the known volumes of the cochlea, vestibule, and semicircular canals). Forty healthy subjects were included and compared to 51 definite MD ears of 50 patients while analyzing the ET-ECochG, which used a self-made bronze foil electrode. The amplitude ratio of the summating potential (SP) to the action potential (AP) (SP/AP) and the area ratio of SP to AP (Asp/Aap) were collected. Relative ELH grade scores were then correlated to ET-ECochG (SP/AP, Asp/Aap).Results: The VR scores showed a better correlation (r = 0.88) with the pure tone average (PTA), disease duration, and vertigo frequency of MD than the Bernaerts scores (grading the cochlea and vestibule separately) (r = 0.22). The SP/AP and Asp/Aap of the unilateral MD patients were statistically comparable to those measured in contralateral ears and the results between the definite MD ears with healthy ears were statistically comparable (p < 0.05). In a ROC analysis Asp/Aap (area under curve, AUC 0.98) significantly (p = 0.01) outperformed SP/AP (AUC 0.91). The total score of ELH, vestibular ELH, and cochlear ELH were also correlated with SP/AP and Asp/Aap. The strongest correlation was found between the Asp/Aap and cochlear ELH (r = 0.60).Conclusion: The 2D volume-referencing grading system was more meaningful than the Bernaerts scores. A correlation was found between ELH revealed by 3D-FLAIR MRI and the SP/AP of ET-ECochG in evaluating definite MD patients. The Asp/Aap appeared a more sensitive and reliable parameter than SP/AP for diagnosing the ELH of the membranous labyrinth. |
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| series | Frontiers in Neurology |
| spelling | doaj.art-cebb7af9ae1a470db08de98f0d38920c2022-12-21T22:05:09ZengFrontiers Media S.A.Frontiers in Neurology1664-22952021-01-011110.3389/fneur.2020.595038595038The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's DiseaseBaihui He0Baihui He1Baihui He2Fan Zhang3Fan Zhang4Fan Zhang5Hui Zheng6Xiayu Sun7Xiayu Sun8Xiayu Sun9Junmin Chen10Junmin Chen11Junmin Chen12Jianyong Chen13Jianyong Chen14Jianyong Chen15Yupeng Liu16Yupeng Liu17Yupeng Liu18Lu Wang19Lu Wang20Lu Wang21Wei Wang22Wei Wang23Wei Wang24Shuna Li25Shuna Li26Shuna Li27Jun Yang28Jun Yang29Jun Yang30Maoli Duan31Maoli Duan32Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Radiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaEar Institute, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, ChinaDepartment of Otolaryngology Head and Neck and Neurotology and Audiology, Karolinska Institute, Karolinska University Hospital, Stockholm, SwedenDepartment of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, SwedenBackground: Although magnetic resonance imaging (MRI) of the membranous labyrinth and electrocochleography (ECochG) have been used to diagnose endolymphatic hydrops (ELH) in patients with Ménière's disease (MD), the relationship between imaging and ECochG is not well-documented.Objectives: This study evaluates the ELH using 3D-FLAIR MRI and extra-tympanic ECochG (ET-ECochG) and correlates the results from 3D-FLAIR MRI to those from ET-ECochG.Materials and Methods: 3D-FLAIR MRI images of 50 patients were assessed using a 2D volume-referencing grading system (VR scores, relative scores according to the known volumes of the cochlea, vestibule, and semicircular canals). Forty healthy subjects were included and compared to 51 definite MD ears of 50 patients while analyzing the ET-ECochG, which used a self-made bronze foil electrode. The amplitude ratio of the summating potential (SP) to the action potential (AP) (SP/AP) and the area ratio of SP to AP (Asp/Aap) were collected. Relative ELH grade scores were then correlated to ET-ECochG (SP/AP, Asp/Aap).Results: The VR scores showed a better correlation (r = 0.88) with the pure tone average (PTA), disease duration, and vertigo frequency of MD than the Bernaerts scores (grading the cochlea and vestibule separately) (r = 0.22). The SP/AP and Asp/Aap of the unilateral MD patients were statistically comparable to those measured in contralateral ears and the results between the definite MD ears with healthy ears were statistically comparable (p < 0.05). In a ROC analysis Asp/Aap (area under curve, AUC 0.98) significantly (p = 0.01) outperformed SP/AP (AUC 0.91). The total score of ELH, vestibular ELH, and cochlear ELH were also correlated with SP/AP and Asp/Aap. The strongest correlation was found between the Asp/Aap and cochlear ELH (r = 0.60).Conclusion: The 2D volume-referencing grading system was more meaningful than the Bernaerts scores. A correlation was found between ELH revealed by 3D-FLAIR MRI and the SP/AP of ET-ECochG in evaluating definite MD patients. The Asp/Aap appeared a more sensitive and reliable parameter than SP/AP for diagnosing the ELH of the membranous labyrinth.https://www.frontiersin.org/articles/10.3389/fneur.2020.595038/fullendolymphatic hydropsmagnetic resonance imagingMénière's diseaseelectrocochleographydiagnosis |
| spellingShingle | Baihui He Baihui He Baihui He Fan Zhang Fan Zhang Fan Zhang Hui Zheng Xiayu Sun Xiayu Sun Xiayu Sun Junmin Chen Junmin Chen Junmin Chen Jianyong Chen Jianyong Chen Jianyong Chen Yupeng Liu Yupeng Liu Yupeng Liu Lu Wang Lu Wang Lu Wang Wei Wang Wei Wang Wei Wang Shuna Li Shuna Li Shuna Li Jun Yang Jun Yang Jun Yang Maoli Duan Maoli Duan The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease Frontiers in Neurology endolymphatic hydrops magnetic resonance imaging Ménière's disease electrocochleography diagnosis |
| title | The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease |
| title_full | The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease |
| title_fullStr | The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease |
| title_full_unstemmed | The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease |
| title_short | The Correlation of a 2D Volume-Referencing Endolymphatic-Hydrops Grading System With Extra-Tympanic Electrocochleography in Patients With Definite Ménière's Disease |
| title_sort | correlation of a 2d volume referencing endolymphatic hydrops grading system with extra tympanic electrocochleography in patients with definite meniere s disease |
| topic | endolymphatic hydrops magnetic resonance imaging Ménière's disease electrocochleography diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.595038/full |
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