Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is up...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2021-07-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/7/3/00984-2020.full |
| _version_ | 1818935037193617408 |
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| author | Fatemeh Saheb Sharif-Askari Narjes Saheb Sharif-Askari Swati Goel Bassam Mahboub Abdul Wahid Ansari Mohamad-Hani Temsah Adel M. Zakri Elaref Ratemi Rifat Hamoudi Qutayba Hamid Rabih Halwani |
| author_facet | Fatemeh Saheb Sharif-Askari Narjes Saheb Sharif-Askari Swati Goel Bassam Mahboub Abdul Wahid Ansari Mohamad-Hani Temsah Adel M. Zakri Elaref Ratemi Rifat Hamoudi Qutayba Hamid Rabih Halwani |
| author_sort | Fatemeh Saheb Sharif-Askari |
| collection | DOAJ |
| description | Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target. |
| first_indexed | 2024-12-20T05:13:48Z |
| format | Article |
| id | doaj.art-cebef528ffc2404f903564c92525f545 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-12-20T05:13:48Z |
| publishDate | 2021-07-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-cebef528ffc2404f903564c92525f5452022-12-21T19:52:13ZengEuropean Respiratory SocietyERJ Open Research2312-05412021-07-017310.1183/23120541.00984-202000984-2020Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severityFatemeh Saheb Sharif-Askari0Narjes Saheb Sharif-Askari1Swati Goel2Bassam Mahboub3Abdul Wahid Ansari4Mohamad-Hani Temsah5Adel M. Zakri6Elaref Ratemi7Rifat Hamoudi8Qutayba Hamid9Rabih Halwani10 Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates Rashid Hospital, Dubai Health Authority, Dubai, United Arab Emirates Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates Immunology Research Lab, Dept of Pediatrics, College of Medicine, King Saud University, Sharjah, Saudi Arabia Dept of Plant Production, Faculty of Agriculture and Food Sciences, King Saud University, Riyadh, Saudi Arabia Dept of Chemical and Process Engineering Technology, Jubail Industrial College, Jubail Industrial City, Saudi Arabia Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates Interleukin (IL)-19, a designated IL-20 subfamily cytokine, has been implicated in inflammatory disorders including rheumatoid arthritis, psoriasis and, lately, asthma. Here, through the analysis of transcriptomic datasets of lung tissue of large asthma cohorts, we report that IL-19 expression is upregulated in asthma and correlates with disease severity. The gene expression of IL-19 was significantly higher in lung tissue from patients with severe and mild/moderate asthma compared to healthy controls. IL-19 protein level, however, was significantly higher in the blood and saliva of patients with severe asthma compared to mild/moderate subgroups as measured by ELISA assay. IL-19 protein level was not affected by corticosteroid treatment in plasma. Our data provide insights into the potential use of IL-19 as a saliva marker for asthma severity and a potential therapeutic target.http://openres.ersjournals.com/content/7/3/00984-2020.full |
| spellingShingle | Fatemeh Saheb Sharif-Askari Narjes Saheb Sharif-Askari Swati Goel Bassam Mahboub Abdul Wahid Ansari Mohamad-Hani Temsah Adel M. Zakri Elaref Ratemi Rifat Hamoudi Qutayba Hamid Rabih Halwani Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity ERJ Open Research |
| title | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
| title_full | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
| title_fullStr | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
| title_full_unstemmed | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
| title_short | Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity |
| title_sort | upregulation of interleukin 19 in severe asthma a potential saliva biomarker for asthma severity |
| url | http://openres.ersjournals.com/content/7/3/00984-2020.full |
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