Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patients
ObjectiveAnxiety and depression are common mental disorders in glioma patients. This study aimed to evaluate the risk factors, prognostic role, and longitudinal changes in anxiety and depression in postoperative glioma patients.MethodsAnxiety and depression were assessed by Hospital Anxiety and Depr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Surgery |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1069709/full |
| _version_ | 1797952103840219136 |
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| author | Xiaohua Wu Dongdong Wang Dan Wang |
| author_facet | Xiaohua Wu Dongdong Wang Dan Wang |
| author_sort | Xiaohua Wu |
| collection | DOAJ |
| description | ObjectiveAnxiety and depression are common mental disorders in glioma patients. This study aimed to evaluate the risk factors, prognostic role, and longitudinal changes in anxiety and depression in postoperative glioma patients.MethodsAnxiety and depression were assessed by Hospital Anxiety and Depression Scale at baseline, month (M) 6, M12, M24 and M36 in 270 glioma patients after surgical resection. Furthermore, comprehensive clinic characteristics and treatment-related information were collected.ResultsGender (female vs. male) (P = 0.014, odds ratio (OR) = 1.974), marital status (single/divorced/widowed vs. married) (P = 0.019, OR = 2.172), Karnofsky performance status (KPS) score (≤70 vs. > 70) (P = 0.002, OR = 2.556), World Health Organization (WHO) classification (high-grade glioma (HGG) vs. low-grade glioma (LGG)) (P = 0.005, OR = 2.155), and postoperative complications (yes vs. not) (P = 0.001, OR = 2.525) were independently related to anxiety occurrence. Marital status (single/divorced/widowed vs. married) (P = 0.034, OR = 2.026), KPS score (≤70 vs. > 70) (P < 0.001, OR = 3.880), WHO classification (HGG vs. LGG) (P = 0.032, OR = 1.810), and postoperative complications (yes vs. not) (P = 0.001, OR = 2.602) were independently related to depression occurrence. Besides, anxiety (P = 0.038) and depression (P = 0.013) were linked with shorter overall survival (OS), and depression was an independent risk factor for worse OS (P = 0.040, hazard ratio = 1.596). More importantly, anxiety and depression remained at a high prevalence during a 3-year follow-up.ConclusionGender, marital status, KPS score, WHO classification, and postoperative complications are risk factors for anxiety and depression; moreover, anxiety and depression are at high prevalence continuously and correlated with worse survival in postoperative glioma patients. |
| first_indexed | 2024-04-10T22:42:09Z |
| format | Article |
| id | doaj.art-cebf23d3baa846299ddfb232fee81300 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-10T22:42:09Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-cebf23d3baa846299ddfb232fee813002023-01-16T04:57:02ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2023-01-01910.3389/fsurg.2022.10697091069709Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patientsXiaohua Wu0Dongdong Wang1Dan Wang2Department of Neurosurgery IV, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaDepartment of Neurosurgery II, The Second Affiliated Hospital of Harbin Medical University, Harbin, ChinaObjectiveAnxiety and depression are common mental disorders in glioma patients. This study aimed to evaluate the risk factors, prognostic role, and longitudinal changes in anxiety and depression in postoperative glioma patients.MethodsAnxiety and depression were assessed by Hospital Anxiety and Depression Scale at baseline, month (M) 6, M12, M24 and M36 in 270 glioma patients after surgical resection. Furthermore, comprehensive clinic characteristics and treatment-related information were collected.ResultsGender (female vs. male) (P = 0.014, odds ratio (OR) = 1.974), marital status (single/divorced/widowed vs. married) (P = 0.019, OR = 2.172), Karnofsky performance status (KPS) score (≤70 vs. > 70) (P = 0.002, OR = 2.556), World Health Organization (WHO) classification (high-grade glioma (HGG) vs. low-grade glioma (LGG)) (P = 0.005, OR = 2.155), and postoperative complications (yes vs. not) (P = 0.001, OR = 2.525) were independently related to anxiety occurrence. Marital status (single/divorced/widowed vs. married) (P = 0.034, OR = 2.026), KPS score (≤70 vs. > 70) (P < 0.001, OR = 3.880), WHO classification (HGG vs. LGG) (P = 0.032, OR = 1.810), and postoperative complications (yes vs. not) (P = 0.001, OR = 2.602) were independently related to depression occurrence. Besides, anxiety (P = 0.038) and depression (P = 0.013) were linked with shorter overall survival (OS), and depression was an independent risk factor for worse OS (P = 0.040, hazard ratio = 1.596). More importantly, anxiety and depression remained at a high prevalence during a 3-year follow-up.ConclusionGender, marital status, KPS score, WHO classification, and postoperative complications are risk factors for anxiety and depression; moreover, anxiety and depression are at high prevalence continuously and correlated with worse survival in postoperative glioma patients.https://www.frontiersin.org/articles/10.3389/fsurg.2022.1069709/fullanxiety and depressiongliomarisk factorsoverall survivallongitudinal variation |
| spellingShingle | Xiaohua Wu Dongdong Wang Dan Wang Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patients Frontiers in Surgery anxiety and depression glioma risk factors overall survival longitudinal variation |
| title | Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patients |
| title_full | Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patients |
| title_fullStr | Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patients |
| title_full_unstemmed | Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patients |
| title_short | Risk factors, prognostic potency, and longitudinal variation of anxiety and depression in postoperative glioma patients |
| title_sort | risk factors prognostic potency and longitudinal variation of anxiety and depression in postoperative glioma patients |
| topic | anxiety and depression glioma risk factors overall survival longitudinal variation |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.1069709/full |
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