Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver Genes
A large proportion of patients with non-small cell lung cancer (NSCLC) are diagnosed with metastatic and incurable advanced lung cancer at the time of discovery, so these patients are given no surgical opportunity and have a low 5-year survival rate. In the era of immunotherapy, many kinds of immune...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Magazine House of Cancer Research on Prevention and Treatment
2023-09-01
|
| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1533 |
| _version_ | 1797671764238532608 |
|---|---|
| author | LI Peng WU Xiaoting GONG Xiaomei |
| author_facet | LI Peng WU Xiaoting GONG Xiaomei |
| author_sort | LI Peng |
| collection | DOAJ |
| description | A large proportion of patients with non-small cell lung cancer (NSCLC) are diagnosed with metastatic and incurable advanced lung cancer at the time of discovery, so these patients are given no surgical opportunity and have a low 5-year survival rate. In the era of immunotherapy, many kinds of immune checkpoint inhibitors (ICIs) have been approved as the first/second-line treatment for patients with advanced NSCLC with negative driving genes and have been combined with radiotherapy as an important treatment strategy for patients with advanced NSCLC. The innovative strategy of combining radiotherapy and immunotherapy has shown feasibility as supported by practical evidence in clinical research. A preclinical experiment of observing the immune mechanism at the molecular and cellular levels preliminarily revealed the interaction among tumor, radiation, and immune system. This paper briefly reviews the progress of combined radiotherapy and immunotherapy in the treatment of advanced NSCLC with negative drvier genes. |
| first_indexed | 2024-03-11T21:20:16Z |
| format | Article |
| id | doaj.art-cec064afa38548a5a5bf1f7e3349a51c |
| institution | Directory Open Access Journal |
| issn | 1000-8578 |
| language | zho |
| last_indexed | 2024-03-11T21:20:16Z |
| publishDate | 2023-09-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-cec064afa38548a5a5bf1f7e3349a51c2023-09-28T08:05:29ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85782023-09-0150984284610.3971/j.issn.1000-8578.2023.22.15338578.2023.22.1533Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver GenesLI Peng0WU Xiaoting1GONG Xiaomei2Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, ChinaDepartment of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, ChinaDepartment of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University, Shanghai 200433, ChinaA large proportion of patients with non-small cell lung cancer (NSCLC) are diagnosed with metastatic and incurable advanced lung cancer at the time of discovery, so these patients are given no surgical opportunity and have a low 5-year survival rate. In the era of immunotherapy, many kinds of immune checkpoint inhibitors (ICIs) have been approved as the first/second-line treatment for patients with advanced NSCLC with negative driving genes and have been combined with radiotherapy as an important treatment strategy for patients with advanced NSCLC. The innovative strategy of combining radiotherapy and immunotherapy has shown feasibility as supported by practical evidence in clinical research. A preclinical experiment of observing the immune mechanism at the molecular and cellular levels preliminarily revealed the interaction among tumor, radiation, and immune system. This paper briefly reviews the progress of combined radiotherapy and immunotherapy in the treatment of advanced NSCLC with negative drvier genes.http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1533advanced non-small cell lung cancernegative driver genesradiotherapy and immunotherapy |
| spellingShingle | LI Peng WU Xiaoting GONG Xiaomei Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver Genes Zhongliu Fangzhi Yanjiu advanced non-small cell lung cancer negative driver genes radiotherapy and immunotherapy |
| title | Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver Genes |
| title_full | Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver Genes |
| title_fullStr | Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver Genes |
| title_full_unstemmed | Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver Genes |
| title_short | Research Progress on Combination of Radiotherapy and Immunotherapy on Advanced Non-small Cell Lung Cancer with Negative Driver Genes |
| title_sort | research progress on combination of radiotherapy and immunotherapy on advanced non small cell lung cancer with negative driver genes |
| topic | advanced non-small cell lung cancer negative driver genes radiotherapy and immunotherapy |
| url | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.1533 |
| work_keys_str_mv | AT lipeng researchprogressoncombinationofradiotherapyandimmunotherapyonadvancednonsmallcelllungcancerwithnegativedrivergenes AT wuxiaoting researchprogressoncombinationofradiotherapyandimmunotherapyonadvancednonsmallcelllungcancerwithnegativedrivergenes AT gongxiaomei researchprogressoncombinationofradiotherapyandimmunotherapyonadvancednonsmallcelllungcancerwithnegativedrivergenes |