Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine
Single-walled carbon nanotube (SWCNT)-based field-effect transistors (FETs) have been explored for use as biological/chemical sensors. Dopamine (DA) is a biomolecule with great clinical significance for disease diagnosis, however, SWCNT FETs lack responsivity and selectivity for its detection due to...
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2014-11-01
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| Series: | Beilstein Journal of Nanotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjnano.5.220 |
| _version_ | 1819047580160491520 |
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| author | Hari Krishna Salila Vijayalal Mohan Jianing An Lianxi Zheng |
| author_facet | Hari Krishna Salila Vijayalal Mohan Jianing An Lianxi Zheng |
| author_sort | Hari Krishna Salila Vijayalal Mohan |
| collection | DOAJ |
| description | Single-walled carbon nanotube (SWCNT)-based field-effect transistors (FETs) have been explored for use as biological/chemical sensors. Dopamine (DA) is a biomolecule with great clinical significance for disease diagnosis, however, SWCNT FETs lack responsivity and selectivity for its detection due to the presence of interfering compounds such as uric acid (UA). Surface modification of CNTs using single-stranded deoxyribonucleic acid (ssDNA) renders the surface responsive to DA and screens the interferent. Due to the presence of different bases in ssDNA, it is necessary to investigate the effect of sequence on the FET-based molecular recognition of DA. SWCNT FETs were decorated with homo- and repeated-base ssDNA sequences, and the electrical response induced by DA in the presence and absence of UA was gauged in terms of the variation in transistor electrical parameters including conductance, transconductance, threshold voltage and hysteresis gap. Our results showed that the response of ssDNA-decorated devices to DA, irrespective of the presence or absence of UA, was DNA sequence dependent and exhibited the trend: G > A > C and GA > GT > AC > CT, for homo- and repeated-base sequences, respectively. The different response of various SWCNT–ssDNA systems to DA underlines the sequence selectivity, whereas the detection of DA in the presence of UA highlights the molecular selectivity of the ssDNA-decorated devices. |
| first_indexed | 2024-12-21T11:02:37Z |
| format | Article |
| id | doaj.art-cec15f32d26a46bab28a1906d83cd8ea |
| institution | Directory Open Access Journal |
| issn | 2190-4286 |
| language | English |
| last_indexed | 2024-12-21T11:02:37Z |
| publishDate | 2014-11-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Nanotechnology |
| spelling | doaj.art-cec15f32d26a46bab28a1906d83cd8ea2022-12-21T19:06:19ZengBeilstein-InstitutBeilstein Journal of Nanotechnology2190-42862014-11-01512113212110.3762/bjnano.5.2202190-4286-5-220Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamineHari Krishna Salila Vijayalal Mohan0Jianing An1Lianxi Zheng2School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore,School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore,School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore,Single-walled carbon nanotube (SWCNT)-based field-effect transistors (FETs) have been explored for use as biological/chemical sensors. Dopamine (DA) is a biomolecule with great clinical significance for disease diagnosis, however, SWCNT FETs lack responsivity and selectivity for its detection due to the presence of interfering compounds such as uric acid (UA). Surface modification of CNTs using single-stranded deoxyribonucleic acid (ssDNA) renders the surface responsive to DA and screens the interferent. Due to the presence of different bases in ssDNA, it is necessary to investigate the effect of sequence on the FET-based molecular recognition of DA. SWCNT FETs were decorated with homo- and repeated-base ssDNA sequences, and the electrical response induced by DA in the presence and absence of UA was gauged in terms of the variation in transistor electrical parameters including conductance, transconductance, threshold voltage and hysteresis gap. Our results showed that the response of ssDNA-decorated devices to DA, irrespective of the presence or absence of UA, was DNA sequence dependent and exhibited the trend: G > A > C and GA > GT > AC > CT, for homo- and repeated-base sequences, respectively. The different response of various SWCNT–ssDNA systems to DA underlines the sequence selectivity, whereas the detection of DA in the presence of UA highlights the molecular selectivity of the ssDNA-decorated devices.https://doi.org/10.3762/bjnano.5.220carbon nanotubedeoxyribonucleic aciddopaminefield-effect transistoruric acid |
| spellingShingle | Hari Krishna Salila Vijayalal Mohan Jianing An Lianxi Zheng Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine Beilstein Journal of Nanotechnology carbon nanotube deoxyribonucleic acid dopamine field-effect transistor uric acid |
| title | Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine |
| title_full | Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine |
| title_fullStr | Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine |
| title_full_unstemmed | Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine |
| title_short | Sequence-dependent electrical response of ssDNA-decorated carbon nanotube, field-effect transistors to dopamine |
| title_sort | sequence dependent electrical response of ssdna decorated carbon nanotube field effect transistors to dopamine |
| topic | carbon nanotube deoxyribonucleic acid dopamine field-effect transistor uric acid |
| url | https://doi.org/10.3762/bjnano.5.220 |
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