Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase

Metabolic changes and propensity for inflammation, fibrosis, and cancer in livers of mice lacking lysosomal acid lipase

Lysosomal acid lipase (LAL) is the sole lysosomal enzyme responsible for the degradation of cholesteryl esters and triacylglycerols at acidic pH. Impaired LAL activity leads to LAL deficiency (LAL-D), a severe and fatal disease characterized by ectopic lysosomal lipid accumulation. Reduced LAL activ...

Full description

Bibliographic Details
Main Authors: Ivan Bradić, Laura Liesinger, Katharina B. Kuentzel, Nemanja Vujić, Michael Trauner, Ruth Birner-Gruenberger, Dagmar Kratky
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Journal of Lipid Research
Subjects:
lysosomal storage disorder
lipid metabolism
cholesterol
non-alcoholic fatty liver disease
lipase/lysosomal
lipids
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001001

Internet

http://www.sciencedirect.com/science/article/pii/S0022227523001001

Similar Items