Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release
The (±)-α-Tocopherol (TP) with vitamin E activity has been encapsulated into biocompatible poly(lactic acid) (PLA) and poly(lactide-<i>co</i>-glycolide) (PLGA) carriers, which results in the formation of well-defined nanosized (d ~200−220 nm) core-shell struct...
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| Format: | Article |
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MDPI AG
2019-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/7/357 |
| _version_ | 1798040080784293888 |
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| author | Norbert Varga Árpád Turcsányi Viktória Hornok Edit Csapó |
| author_facet | Norbert Varga Árpád Turcsányi Viktória Hornok Edit Csapó |
| author_sort | Norbert Varga |
| collection | DOAJ |
| description | The (±)-α-Tocopherol (TP) with vitamin E activity has been encapsulated into biocompatible poly(lactic acid) (PLA) and poly(lactide-<i>co</i>-glycolide) (PLGA) carriers, which results in the formation of well-defined nanosized (d ~200−220 nm) core-shell structured particles (NPs) with 15−19% of drug loading (DL%). The optimal ratios of the polymer carriers, the TP active drug as well as the applied Pluronic F127 (PLUR) non-ionic stabilizing surfactant, have been determined to obtain NPs with a TP core and a polymer shell with high encapsulation efficiency (EE%) (69%). The size and the structure of the prepared core-shell NPs as well as the interaction of the carriers and the PLUR with the TP molecules have been determined by transmission electron microscopy (TEM), dynamic light scattering (DLS), infrared spectroscopy (FT-IR) and turbidity studies, respectively. Moreover, the dissolution of the TP from the polymer NPs has been investigated by spectrophotometric measurements. It was clearly confirmed that increase in the EE% from ca. 70% (PLA/TP) to ca. 88% (PLGA65/TP) results in the controlled release of the hydrophobic TP molecules (7 h, PLA/TP: 34%; PLGA75/TP: 25%; PLGA65/TP: 18%). By replacing the PLA carrier to PLGA, ca. 15% more active substance can be encapsulated in the core (PLA/TP: 65%; PLGA65/TP: 80%). |
| first_indexed | 2024-04-11T22:02:34Z |
| format | Article |
| id | doaj.art-cec4efb6be8b4b60b139012a345e282e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T22:02:34Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cec4efb6be8b4b60b139012a345e282e2022-12-22T04:00:51ZengMDPI AGPharmaceutics1999-49232019-07-0111735710.3390/pharmaceutics11070357pharmaceutics11070357Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug ReleaseNorbert Varga0Árpád Turcsányi1Viktória Hornok2Edit Csapó3Interdisciplinary Excellence Centre, Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich B. square 1, H-6720 Szeged, HungaryInterdisciplinary Excellence Centre, Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich B. square 1, H-6720 Szeged, HungaryInterdisciplinary Excellence Centre, Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich B. square 1, H-6720 Szeged, HungaryInterdisciplinary Excellence Centre, Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich B. square 1, H-6720 Szeged, HungaryThe (±)-α-Tocopherol (TP) with vitamin E activity has been encapsulated into biocompatible poly(lactic acid) (PLA) and poly(lactide-<i>co</i>-glycolide) (PLGA) carriers, which results in the formation of well-defined nanosized (d ~200−220 nm) core-shell structured particles (NPs) with 15−19% of drug loading (DL%). The optimal ratios of the polymer carriers, the TP active drug as well as the applied Pluronic F127 (PLUR) non-ionic stabilizing surfactant, have been determined to obtain NPs with a TP core and a polymer shell with high encapsulation efficiency (EE%) (69%). The size and the structure of the prepared core-shell NPs as well as the interaction of the carriers and the PLUR with the TP molecules have been determined by transmission electron microscopy (TEM), dynamic light scattering (DLS), infrared spectroscopy (FT-IR) and turbidity studies, respectively. Moreover, the dissolution of the TP from the polymer NPs has been investigated by spectrophotometric measurements. It was clearly confirmed that increase in the EE% from ca. 70% (PLA/TP) to ca. 88% (PLGA65/TP) results in the controlled release of the hydrophobic TP molecules (7 h, PLA/TP: 34%; PLGA75/TP: 25%; PLGA65/TP: 18%). By replacing the PLA carrier to PLGA, ca. 15% more active substance can be encapsulated in the core (PLA/TP: 65%; PLGA65/TP: 80%).https://www.mdpi.com/1999-4923/11/7/357vitamin EtocopherolPLAPLGAcore-shell nanoparticlesdrug deliverycontrolled drug release |
| spellingShingle | Norbert Varga Árpád Turcsányi Viktória Hornok Edit Csapó Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release Pharmaceutics vitamin E tocopherol PLA PLGA core-shell nanoparticles drug delivery controlled drug release |
| title | Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release |
| title_full | Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release |
| title_fullStr | Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release |
| title_full_unstemmed | Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release |
| title_short | Vitamin E-Loaded PLA- and PLGA-Based Core-Shell Nanoparticles: Synthesis, Structure Optimization and Controlled Drug Release |
| title_sort | vitamin e loaded pla and plga based core shell nanoparticles synthesis structure optimization and controlled drug release |
| topic | vitamin E tocopherol PLA PLGA core-shell nanoparticles drug delivery controlled drug release |
| url | https://www.mdpi.com/1999-4923/11/7/357 |
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