Solubility and ADMET profiles of short oligomers of lactic acid
Polylactic acid (PLA) is a polymer with an increased potential to be used in different medical applications, including tissue engineering and drug-carries. The use of PLA in medical applications implies the evaluation of the human organism's response to the polymer inserting and to its degradat...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
International Association of Physical Chemists (IAPC)
2020-06-01
|
| Series: | ADMET and DMPK |
| Online Access: | https://pub.iapchem.org/ojs/index.php/admet/article/view/843 |
| _version_ | 1828493365128200192 |
|---|---|
| author | Daniela Dascălu Diana Larisa Roman Madalina Filip Alecu Aurel Ciorsac Vasile Ostafe Adriana Isvoran |
| author_facet | Daniela Dascălu Diana Larisa Roman Madalina Filip Alecu Aurel Ciorsac Vasile Ostafe Adriana Isvoran |
| author_sort | Daniela Dascălu |
| collection | DOAJ |
| description | Polylactic acid (PLA) is a polymer with an increased potential to be used in different medical applications, including tissue engineering and drug-carries. The use of PLA in medical applications implies the evaluation of the human organism's response to the polymer inserting and to its degradation products. Consequently, within this study, we have investigated the solubility and ADMET profiles of the short oligomers (having the molecular weight lower than 3000 Da) resulting in degradation products of PLA. There is a linear decrease of the molar solubility of investigated oligomers with molecular weight. The results that are obtained also reveal that short oligomers of PLA have promising pharmacological profiles and limited toxicological effects on humans. These oligomers are predicted as potential inhibitors of the organic anion transporting peptides OATP1B1 and OATP1B3, they present minor probability to affect the androgen and glucocorticoid receptors, have a weak potential of hepatotoxicity, and may produce eye injuries. These outcomes may be used to guide or to supplement in vitro and/or in vivo toxicity tests such as to enhance the biodegradation properties of the biopolymer. |
| first_indexed | 2024-12-11T11:37:33Z |
| format | Article |
| id | doaj.art-ceca213237d448048adf051ba297f23d |
| institution | Directory Open Access Journal |
| issn | 1848-7718 |
| language | English |
| last_indexed | 2024-12-11T11:37:33Z |
| publishDate | 2020-06-01 |
| publisher | International Association of Physical Chemists (IAPC) |
| record_format | Article |
| series | ADMET and DMPK |
| spelling | doaj.art-ceca213237d448048adf051ba297f23d2022-12-22T01:08:43ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182020-06-018410.5599/admet.843Solubility and ADMET profiles of short oligomers of lactic acidDaniela Dascălu0Diana Larisa Roman1Madalina Filip2Alecu Aurel Ciorsac3Vasile Ostafe4Adriana Isvoran5Department of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, RomaniaDepartment of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, RomaniaDepartment of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, RomaniaDepartment of Physical Education and Sport, University Politehnica Timișoara, Timișoara, RomaniaDepartment of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, RomaniaDepartment of Biology-Chemistry and Advanced Environmental Research Laboratories, West University of Timișoara, Timișoara, RomaniaPolylactic acid (PLA) is a polymer with an increased potential to be used in different medical applications, including tissue engineering and drug-carries. The use of PLA in medical applications implies the evaluation of the human organism's response to the polymer inserting and to its degradation products. Consequently, within this study, we have investigated the solubility and ADMET profiles of the short oligomers (having the molecular weight lower than 3000 Da) resulting in degradation products of PLA. There is a linear decrease of the molar solubility of investigated oligomers with molecular weight. The results that are obtained also reveal that short oligomers of PLA have promising pharmacological profiles and limited toxicological effects on humans. These oligomers are predicted as potential inhibitors of the organic anion transporting peptides OATP1B1 and OATP1B3, they present minor probability to affect the androgen and glucocorticoid receptors, have a weak potential of hepatotoxicity, and may produce eye injuries. These outcomes may be used to guide or to supplement in vitro and/or in vivo toxicity tests such as to enhance the biodegradation properties of the biopolymer.https://pub.iapchem.org/ojs/index.php/admet/article/view/843 |
| spellingShingle | Daniela Dascălu Diana Larisa Roman Madalina Filip Alecu Aurel Ciorsac Vasile Ostafe Adriana Isvoran Solubility and ADMET profiles of short oligomers of lactic acid ADMET and DMPK |
| title | Solubility and ADMET profiles of short oligomers of lactic acid |
| title_full | Solubility and ADMET profiles of short oligomers of lactic acid |
| title_fullStr | Solubility and ADMET profiles of short oligomers of lactic acid |
| title_full_unstemmed | Solubility and ADMET profiles of short oligomers of lactic acid |
| title_short | Solubility and ADMET profiles of short oligomers of lactic acid |
| title_sort | solubility and admet profiles of short oligomers of lactic acid |
| url | https://pub.iapchem.org/ojs/index.php/admet/article/view/843 |
| work_keys_str_mv | AT danieladascalu solubilityandadmetprofilesofshortoligomersoflacticacid AT dianalarisaroman solubilityandadmetprofilesofshortoligomersoflacticacid AT madalinafilip solubilityandadmetprofilesofshortoligomersoflacticacid AT alecuaurelciorsac solubilityandadmetprofilesofshortoligomersoflacticacid AT vasileostafe solubilityandadmetprofilesofshortoligomersoflacticacid AT adrianaisvoran solubilityandadmetprofilesofshortoligomersoflacticacid |