Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway.

Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway.

Alteration of functional regenerative properties of parenchymal lung fibroblasts is widely proposed as a pathogenic mechanism for chronic obstructive pulmonary disease (COPD). However, what these functions are and how they are impaired in COPD remain poorly understood. Apart from the role of fibrobl...

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Main Authors: Florence Figeac, Maylis Dagouassat, Meriem Mahrouf-Yorgov, Sabine Le Gouvello, Céline Trébeau, Angeliqua Sayed, Jean-Baptiste Stern, Pierre Validire, Jean-Luc Dubois-Randé, Jorge Boczkowski, Isabelle Mus-Veteau, Anne-Marie Rodriguez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4376723?pdf=render

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