ORAI2 modulates store-operated calcium entry and T cell-mediated immunity
Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14714 |
| _version_ | 1818342036359610368 |
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| author | Martin Vaeth Jun Yang Megumi Yamashita Isabelle Zee Miriam Eckstein Camille Knosp Ulrike Kaufmann Peter Karoly Jani Rodrigo S. Lacruz Veit Flockerzi Imre Kacskovics Murali Prakriya Stefan Feske |
| author_facet | Martin Vaeth Jun Yang Megumi Yamashita Isabelle Zee Miriam Eckstein Camille Knosp Ulrike Kaufmann Peter Karoly Jani Rodrigo S. Lacruz Veit Flockerzi Imre Kacskovics Murali Prakriya Stefan Feske |
| author_sort | Martin Vaeth |
| collection | DOAJ |
| description | Ca2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune responses. |
| first_indexed | 2024-12-13T16:08:18Z |
| format | Article |
| id | doaj.art-cecf348141a04e5d97c610a4720fbbd4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:08:18Z |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cecf348141a04e5d97c610a4720fbbd42022-12-21T23:39:00ZengNature PortfolioNature Communications2041-17232017-03-018111710.1038/ncomms14714ORAI2 modulates store-operated calcium entry and T cell-mediated immunityMartin Vaeth0Jun Yang1Megumi Yamashita2Isabelle Zee3Miriam Eckstein4Camille Knosp5Ulrike Kaufmann6Peter Karoly Jani7Rodrigo S. Lacruz8Veit Flockerzi9Imre Kacskovics10Murali Prakriya11Stefan Feske12Department of Pathology, Experimental Pathology Program, New York University School of MedicineDepartment of Pathology, Experimental Pathology Program, New York University School of MedicineDepartment of Pharmacology, Northwestern University, Feinberg School of MedicineDepartment of Pathology, Experimental Pathology Program, New York University School of MedicineNYU College of Dentistry, New York UniversityDepartment of Pathology, Experimental Pathology Program, New York University School of MedicineDepartment of Pathology, Experimental Pathology Program, New York University School of MedicineImmunoGenesNYU College of Dentistry, New York UniversityExperimental and Clinical Pharmacology and Toxicology, School of Medicine, Saarland UniversityImmunoGenesDepartment of Pharmacology, Northwestern University, Feinberg School of MedicineDepartment of Pathology, Experimental Pathology Program, New York University School of MedicineCa2+ release-activated Ca2+(CRAC) channels are essential for protective immunity, but the immunological functions of the three ORAI homologues that form CRAC channels are unclear. Here the authors show that ORAI1 and ORAI2 form heteromeric CRAC channels, which fine-tune T cell activation and immune responses.https://doi.org/10.1038/ncomms14714 |
| spellingShingle | Martin Vaeth Jun Yang Megumi Yamashita Isabelle Zee Miriam Eckstein Camille Knosp Ulrike Kaufmann Peter Karoly Jani Rodrigo S. Lacruz Veit Flockerzi Imre Kacskovics Murali Prakriya Stefan Feske ORAI2 modulates store-operated calcium entry and T cell-mediated immunity Nature Communications |
| title | ORAI2 modulates store-operated calcium entry and T cell-mediated immunity |
| title_full | ORAI2 modulates store-operated calcium entry and T cell-mediated immunity |
| title_fullStr | ORAI2 modulates store-operated calcium entry and T cell-mediated immunity |
| title_full_unstemmed | ORAI2 modulates store-operated calcium entry and T cell-mediated immunity |
| title_short | ORAI2 modulates store-operated calcium entry and T cell-mediated immunity |
| title_sort | orai2 modulates store operated calcium entry and t cell mediated immunity |
| url | https://doi.org/10.1038/ncomms14714 |
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