Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation
Objective: Inflammation is thought to play a role in the pathogenesis of atrial fibrillation. The relationship between CD40 ligand (CD40L), a prothrombotic and proinflammatory molecule, and lone atrial fibrillation was presently investigated for the first time. Levels of serum CD40L were also teste...
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| Format: | Article |
| Language: | English |
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KARE Publishing
2016-07-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-03061 |
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| author | Evin Bozçalı Veli Polat Gönül Kutlu Selçuk Opan Nurcan Paker Turgut Uygun Barış Ökçün Osman Karakaya |
| author_facet | Evin Bozçalı Veli Polat Gönül Kutlu Selçuk Opan Nurcan Paker Turgut Uygun Barış Ökçün Osman Karakaya |
| author_sort | Evin Bozçalı |
| collection | DOAJ |
| description | Objective: Inflammation is thought to play a role in the pathogenesis of atrial fibrillation. The relationship between CD40 ligand (CD40L), a prothrombotic and proinflammatory molecule, and lone atrial fibrillation was presently investigated for the first time. Levels of serum CD40L were also tested, regarding potential to distinguish patients with lone atrial fibrillation from healthy individuals.
Methods: Presently included were 35 patients with lone persistent atrial fibrillation and a control group of 30 healthy individuals. Serum levels of CD40L and high-sensitive C-reactive protein (hs-CRP) were measured, and transthoracic echocardiography was performed.
Results: Mean serum CD40L, hs-CRP, left ventricular end-diastolic diameter, and left atrial diameter values were significantly higher in the group with lone persistent atrial fibrillation than in the control group (7.4+-3.5 ng/mL vs 4.3+-1.2 ng/mL, p<0.0001; 3.7+-1.6 mg/L vs 1.7+-0.8 mg/L, p<0.0001; 53.0+-4.2 mm vs 46.0+-3.8, p<0.0001; 43.5+-3.5 mm vs 33.7+-3.5, p<0.0001, respectively). Serum CD40L levels were positively correlated with left atrial diameter (r=0.81, p<0.0001) and hs-CRP (r=0.72, p<0.0001). Receiver operating characteristic curve analysis revealed that serum CD40L at the optimal cut-off level of >4.5 ng/mL successfully discriminated patients with lone atrial fibrillation from controls (area under the curve: 0.847; 95% confidence interval: 0.759–0.934; p<0.0001).
Conclusion: The present findings suggest that CD40L levels play a crucial role in the development of lone atrial fibrillation. In addition, results support that regular clinical follow-up of these patients is necessary, due to increased cardiovascular disease risk, determined by elevated CD40L levels. |
| first_indexed | 2024-04-10T12:25:57Z |
| format | Article |
| id | doaj.art-ced112cf88214b419901e7b81c3fcc7d |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T12:25:57Z |
| publishDate | 2016-07-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-ced112cf88214b419901e7b81c3fcc7d2023-02-15T16:15:12ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692016-07-0144538939610.5543/tkda.2016.03061TKDA-03061Relationship between serum level of CD40 ligand and persistent lone atrial fibrillationEvin Bozçalı0Veli Polat1Gönül Kutlu2Selçuk Opan3Nurcan Paker4Turgut Uygun5Barış Ökçün6Osman Karakaya7Department of Cardiology, Koç University School of Medicine, Istanbul, TurkeyDepartment of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, TurkeyDepartment of Cardiology, Istinye State Hospital, Istanbul, TurkeyDepartment of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, TurkeyDuzen Laboratory, Mecidiyekoy, Istanbul, TurkeyDepartment of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, TurkeyDepartment of Cardiology, Istanbul University Institute of Cardiology, Istanbul, TurkeyDepartment of Cardiology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, TurkeyObjective: Inflammation is thought to play a role in the pathogenesis of atrial fibrillation. The relationship between CD40 ligand (CD40L), a prothrombotic and proinflammatory molecule, and lone atrial fibrillation was presently investigated for the first time. Levels of serum CD40L were also tested, regarding potential to distinguish patients with lone atrial fibrillation from healthy individuals. Methods: Presently included were 35 patients with lone persistent atrial fibrillation and a control group of 30 healthy individuals. Serum levels of CD40L and high-sensitive C-reactive protein (hs-CRP) were measured, and transthoracic echocardiography was performed. Results: Mean serum CD40L, hs-CRP, left ventricular end-diastolic diameter, and left atrial diameter values were significantly higher in the group with lone persistent atrial fibrillation than in the control group (7.4+-3.5 ng/mL vs 4.3+-1.2 ng/mL, p<0.0001; 3.7+-1.6 mg/L vs 1.7+-0.8 mg/L, p<0.0001; 53.0+-4.2 mm vs 46.0+-3.8, p<0.0001; 43.5+-3.5 mm vs 33.7+-3.5, p<0.0001, respectively). Serum CD40L levels were positively correlated with left atrial diameter (r=0.81, p<0.0001) and hs-CRP (r=0.72, p<0.0001). Receiver operating characteristic curve analysis revealed that serum CD40L at the optimal cut-off level of >4.5 ng/mL successfully discriminated patients with lone atrial fibrillation from controls (area under the curve: 0.847; 95% confidence interval: 0.759–0.934; p<0.0001). Conclusion: The present findings suggest that CD40L levels play a crucial role in the development of lone atrial fibrillation. In addition, results support that regular clinical follow-up of these patients is necessary, due to increased cardiovascular disease risk, determined by elevated CD40L levels.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-03061atrial fibrillationcd40 ligandinflammation. |
| spellingShingle | Evin Bozçalı Veli Polat Gönül Kutlu Selçuk Opan Nurcan Paker Turgut Uygun Barış Ökçün Osman Karakaya Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation Türk Kardiyoloji Derneği Arşivi atrial fibrillation cd40 ligand inflammation. |
| title | Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation |
| title_full | Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation |
| title_fullStr | Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation |
| title_full_unstemmed | Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation |
| title_short | Relationship between serum level of CD40 ligand and persistent lone atrial fibrillation |
| title_sort | relationship between serum level of cd40 ligand and persistent lone atrial fibrillation |
| topic | atrial fibrillation cd40 ligand inflammation. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-03061 |
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