No Significant Effects of IL-23 on Initiating and Perpetuating the Axial Spondyloarthritis: The Reasons for the Failure of IL-23 Inhibitors

No Significant Effects of IL-23 on Initiating and Perpetuating the Axial Spondyloarthritis: The Reasons for the Failure of IL-23 Inhibitors

Axial spondyloarthritis (axSpA) is comprised of ankylosing spondylitis (AS) and non-radiographic axSpA. In recent years, the involvement of the interleukin (IL)-23/IL-17 axis in the pathophysiology of axSpA has been widely proposed. Since IL-23 is an upstream activating cytokine of IL-17, theoretica...

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Bibliographic Details
Main Authors: Hua Zhang, Han-Lei Jiang, Sheng-Ming Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
axial spondyloarthritis
IL-23
Th17 cells
IL-17
IL-23 inhibitors
ankylosing spondylitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.818413/full

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