Recent Advances in Biocatalysis for Drug Synthesis
Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also plays a role in drug discovery and can support many active ingredient syntheses at an early stage to build up entire...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/964 |
| _version_ | 1797501465733890048 |
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| author | Alina Kinner Philipp Nerke Regine Siedentop Till Steinmetz Thomas Classen Katrin Rosenthal Markus Nett Jörg Pietruszka Stephan Lütz |
| author_facet | Alina Kinner Philipp Nerke Regine Siedentop Till Steinmetz Thomas Classen Katrin Rosenthal Markus Nett Jörg Pietruszka Stephan Lütz |
| author_sort | Alina Kinner |
| collection | DOAJ |
| description | Biocatalysis is constantly providing novel options for the synthesis of active pharmaceutical ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also plays a role in drug discovery and can support many active ingredient syntheses at an early stage to build up entire scaffolds in a targeted and preparative manner. Recent progress in recruiting new enzymes by genome mining and screening or adapting their substrate, as well as product scope, by protein engineering has made biocatalysts a competitive tool applied in academic and industrial spheres. This is especially true for the advances in the field of nonribosomal peptide synthesis and enzyme cascades that are expanding the capabilities for the discovery and synthesis of new bioactive compounds via biotransformation. Here we highlight some of the most recent developments to add to the portfolio of biocatalysis with special relevance for the synthesis and late-stage functionalization of APIs, in order to bypass pure chemical processes. |
| first_indexed | 2024-03-10T03:18:48Z |
| format | Article |
| id | doaj.art-ced19109aa7f4727916473fcec86ad77 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:18:48Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ced19109aa7f4727916473fcec86ad772023-11-23T10:09:07ZengMDPI AGBiomedicines2227-90592022-04-0110596410.3390/biomedicines10050964Recent Advances in Biocatalysis for Drug SynthesisAlina Kinner0Philipp Nerke1Regine Siedentop2Till Steinmetz3Thomas Classen4Katrin Rosenthal5Markus Nett6Jörg Pietruszka7Stephan Lütz8Chair for Bioprocess Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyChair for Bioprocess Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyChair for Bioprocess Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyLaboratory for Technical Biology, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyInstitute of Bio- and Geosciences: Biotechnology (IBG-1), Forschungszentrum Jülich, 52428 Jülich, GermanyChair for Bioprocess Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyLaboratory for Technical Biology, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyInstitute of Bio- and Geosciences: Biotechnology (IBG-1), Forschungszentrum Jülich, 52428 Jülich, GermanyChair for Bioprocess Engineering, Department of Biochemical and Chemical Engineering, TU Dortmund University, 44227 Dortmund, GermanyBiocatalysis is constantly providing novel options for the synthesis of active pharmaceutical ingredients (APIs). In addition to drug development and manufacturing, biocatalysis also plays a role in drug discovery and can support many active ingredient syntheses at an early stage to build up entire scaffolds in a targeted and preparative manner. Recent progress in recruiting new enzymes by genome mining and screening or adapting their substrate, as well as product scope, by protein engineering has made biocatalysts a competitive tool applied in academic and industrial spheres. This is especially true for the advances in the field of nonribosomal peptide synthesis and enzyme cascades that are expanding the capabilities for the discovery and synthesis of new bioactive compounds via biotransformation. Here we highlight some of the most recent developments to add to the portfolio of biocatalysis with special relevance for the synthesis and late-stage functionalization of APIs, in order to bypass pure chemical processes.https://www.mdpi.com/2227-9059/10/5/964biotransformationactive pharmaceutical ingredient (API)drug discoverynonribosomal peptide synthesisprotein engineeringscaffold forming |
| spellingShingle | Alina Kinner Philipp Nerke Regine Siedentop Till Steinmetz Thomas Classen Katrin Rosenthal Markus Nett Jörg Pietruszka Stephan Lütz Recent Advances in Biocatalysis for Drug Synthesis Biomedicines biotransformation active pharmaceutical ingredient (API) drug discovery nonribosomal peptide synthesis protein engineering scaffold forming |
| title | Recent Advances in Biocatalysis for Drug Synthesis |
| title_full | Recent Advances in Biocatalysis for Drug Synthesis |
| title_fullStr | Recent Advances in Biocatalysis for Drug Synthesis |
| title_full_unstemmed | Recent Advances in Biocatalysis for Drug Synthesis |
| title_short | Recent Advances in Biocatalysis for Drug Synthesis |
| title_sort | recent advances in biocatalysis for drug synthesis |
| topic | biotransformation active pharmaceutical ingredient (API) drug discovery nonribosomal peptide synthesis protein engineering scaffold forming |
| url | https://www.mdpi.com/2227-9059/10/5/964 |
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