Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures
Weightlessness and physical inactivity have deleterious cardiovascular effects. The space environment and its ground-based models offer conditions to study the cardiovascular effects of physical inactivity in the absence of other vascular risk factors, particularly at the macro- and microcirculatory...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2020.00952/full |
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| author | Nastassia Navasiolava Ming Yuan Ronan Murphy Adrien Robin Adrien Robin Mickael Coupé Linjie Wang Asmaa Alameddine Guillemette Gauquelin-Koch Claude Gharib Yinghui Li Marc-Antoine Custaud Marc-Antoine Custaud |
| author_facet | Nastassia Navasiolava Ming Yuan Ronan Murphy Adrien Robin Adrien Robin Mickael Coupé Linjie Wang Asmaa Alameddine Guillemette Gauquelin-Koch Claude Gharib Yinghui Li Marc-Antoine Custaud Marc-Antoine Custaud |
| author_sort | Nastassia Navasiolava |
| collection | DOAJ |
| description | Weightlessness and physical inactivity have deleterious cardiovascular effects. The space environment and its ground-based models offer conditions to study the cardiovascular effects of physical inactivity in the absence of other vascular risk factors, particularly at the macro- and microcirculatory levels. However, the mechanisms involved in vascular dysfunction and remodeling are not sufficiently studied in the context of weightlessness and its analogs including models of physical inactivity. Here, we summarize vascular and microvascular changes induced by space flight and observed in models of microgravity and physical inactivity and review the effects of prophylactic strategies (i.e., countermeasures) on vascular and microvascular function. We discuss physical (e.g., exercise, vibration, lower body negative pressure, and artificial gravity) and nutritional/pharmacological (e.g., caloric restriction, resveratrol, and other vegetal extracts) countermeasures. Currently, exercise countermeasure appears to be the most effective to protect vascular function. Although pharmacological countermeasures are not currently considered to fight vascular changes due to microgravity, nutritional countermeasures are very promising. Dietary supplements/natural health products, especially plant extracts, should be extensively studied. The best prophylactic strategy is likely a combination of countermeasures that are effective not only at the cardiovascular level but also for the organism as a whole, but this strategy remains to be determined. |
| first_indexed | 2024-12-12T13:37:17Z |
| format | Article |
| id | doaj.art-ced29d13ba3f4a13923cb86da3a52944 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-12T13:37:17Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-ced29d13ba3f4a13923cb86da3a529442022-12-22T00:22:54ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-08-011110.3389/fphys.2020.00952538805Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and CountermeasuresNastassia Navasiolava0Ming Yuan1Ronan Murphy2Adrien Robin3Adrien Robin4Mickael Coupé5Linjie Wang6Asmaa Alameddine7Guillemette Gauquelin-Koch8Claude Gharib9Yinghui Li10Marc-Antoine Custaud11Marc-Antoine Custaud12Clinical Research Center, CHU d’Angers, Angers, FranceState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center (ACC), Beijing, ChinaSchool of Health and Human Performance, Faculty of Science & Health, Dublin City University, Dublin, IrelandClinical Research Center, CHU d’Angers, Angers, FranceMitovasc, UMR INSERM 1083-CNRS 6015, Université d’Angers, Angers, FranceMitovasc, UMR INSERM 1083-CNRS 6015, Université d’Angers, Angers, FranceState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center (ACC), Beijing, ChinaMitovasc, UMR INSERM 1083-CNRS 6015, Université d’Angers, Angers, FranceCentre National d’Études Spatiales (CNES), Paris, FranceInstitut NeuroMyoGène, Faculté de Médecine Lyon-Est, Université de Lyon, Lyon, FranceState Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center (ACC), Beijing, ChinaClinical Research Center, CHU d’Angers, Angers, FranceMitovasc, UMR INSERM 1083-CNRS 6015, Université d’Angers, Angers, FranceWeightlessness and physical inactivity have deleterious cardiovascular effects. The space environment and its ground-based models offer conditions to study the cardiovascular effects of physical inactivity in the absence of other vascular risk factors, particularly at the macro- and microcirculatory levels. However, the mechanisms involved in vascular dysfunction and remodeling are not sufficiently studied in the context of weightlessness and its analogs including models of physical inactivity. Here, we summarize vascular and microvascular changes induced by space flight and observed in models of microgravity and physical inactivity and review the effects of prophylactic strategies (i.e., countermeasures) on vascular and microvascular function. We discuss physical (e.g., exercise, vibration, lower body negative pressure, and artificial gravity) and nutritional/pharmacological (e.g., caloric restriction, resveratrol, and other vegetal extracts) countermeasures. Currently, exercise countermeasure appears to be the most effective to protect vascular function. Although pharmacological countermeasures are not currently considered to fight vascular changes due to microgravity, nutritional countermeasures are very promising. Dietary supplements/natural health products, especially plant extracts, should be extensively studied. The best prophylactic strategy is likely a combination of countermeasures that are effective not only at the cardiovascular level but also for the organism as a whole, but this strategy remains to be determined.https://www.frontiersin.org/article/10.3389/fphys.2020.00952/fullvascular deconditioningendotheliumvascular remodelingvascular riskpreventionshear stress |
| spellingShingle | Nastassia Navasiolava Ming Yuan Ronan Murphy Adrien Robin Adrien Robin Mickael Coupé Linjie Wang Asmaa Alameddine Guillemette Gauquelin-Koch Claude Gharib Yinghui Li Marc-Antoine Custaud Marc-Antoine Custaud Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures Frontiers in Physiology vascular deconditioning endothelium vascular remodeling vascular risk prevention shear stress |
| title | Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures |
| title_full | Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures |
| title_fullStr | Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures |
| title_full_unstemmed | Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures |
| title_short | Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures |
| title_sort | vascular and microvascular dysfunction induced by microgravity and its analogs in humans mechanisms and countermeasures |
| topic | vascular deconditioning endothelium vascular remodeling vascular risk prevention shear stress |
| url | https://www.frontiersin.org/article/10.3389/fphys.2020.00952/full |
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