Mitophagy in Yeast: Decades of Research
Mitophagy, the selective degradation of mitochondria by autophagy, is one of the most important mechanisms of mitochondrial quality control, and its proper functioning is essential for cellular homeostasis. In this review, we describe the most important milestones achieved during almost 2 decades of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/12/3541 |
| _version_ | 1797505919910674432 |
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| author | Ingrid Bhatia-Kissova Nadine Camougrand |
| author_facet | Ingrid Bhatia-Kissova Nadine Camougrand |
| author_sort | Ingrid Bhatia-Kissova |
| collection | DOAJ |
| description | Mitophagy, the selective degradation of mitochondria by autophagy, is one of the most important mechanisms of mitochondrial quality control, and its proper functioning is essential for cellular homeostasis. In this review, we describe the most important milestones achieved during almost 2 decades of research on yeasts, which shed light on the molecular mechanisms, regulation, and role of the Atg32 receptor in this process. We analyze the role of ROS in mitophagy and discuss the physiological roles of mitophagy in unicellular organisms, such as yeast; these roles are very different from those in mammals. Additionally, we discuss some of the different tools available for studying mitophagy. |
| first_indexed | 2024-03-10T04:26:11Z |
| format | Article |
| id | doaj.art-ced482d139ad4d7d93792e186ed2aac7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T04:26:11Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-ced482d139ad4d7d93792e186ed2aac72023-11-23T07:39:13ZengMDPI AGCells2073-44092021-12-011012354110.3390/cells10123541Mitophagy in Yeast: Decades of ResearchIngrid Bhatia-Kissova0Nadine Camougrand1Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Ilkovičova 6, 84215 Bratislava, SlovakiaCNRS, UMR 5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, FranceMitophagy, the selective degradation of mitochondria by autophagy, is one of the most important mechanisms of mitochondrial quality control, and its proper functioning is essential for cellular homeostasis. In this review, we describe the most important milestones achieved during almost 2 decades of research on yeasts, which shed light on the molecular mechanisms, regulation, and role of the Atg32 receptor in this process. We analyze the role of ROS in mitophagy and discuss the physiological roles of mitophagy in unicellular organisms, such as yeast; these roles are very different from those in mammals. Additionally, we discuss some of the different tools available for studying mitophagy.https://www.mdpi.com/2073-4409/10/12/3541yeastmitochondriaquality controlmitophagyAtg32 protein |
| spellingShingle | Ingrid Bhatia-Kissova Nadine Camougrand Mitophagy in Yeast: Decades of Research Cells yeast mitochondria quality control mitophagy Atg32 protein |
| title | Mitophagy in Yeast: Decades of Research |
| title_full | Mitophagy in Yeast: Decades of Research |
| title_fullStr | Mitophagy in Yeast: Decades of Research |
| title_full_unstemmed | Mitophagy in Yeast: Decades of Research |
| title_short | Mitophagy in Yeast: Decades of Research |
| title_sort | mitophagy in yeast decades of research |
| topic | yeast mitochondria quality control mitophagy Atg32 protein |
| url | https://www.mdpi.com/2073-4409/10/12/3541 |
| work_keys_str_mv | AT ingridbhatiakissova mitophagyinyeastdecadesofresearch AT nadinecamougrand mitophagyinyeastdecadesofresearch |