Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020
Myxobacteria feature unique biological characteristics, including their capability to glide on the surface, undergo different multicellular developmental stages and produce structurally unique natural products such as the catecholate-type siderophores myxochelins A and B. Herein, we report the isola...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/10/1959 |
| _version_ | 1797471101977100288 |
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| author | Dorothy A. Okoth Joachim J. Hug Ronald Garcia Rolf Müller |
| author_facet | Dorothy A. Okoth Joachim J. Hug Ronald Garcia Rolf Müller |
| author_sort | Dorothy A. Okoth |
| collection | DOAJ |
| description | Myxobacteria feature unique biological characteristics, including their capability to glide on the surface, undergo different multicellular developmental stages and produce structurally unique natural products such as the catecholate-type siderophores myxochelins A and B. Herein, we report the isolation, structure elucidation and a proposed biosynthesis of the new congener myxochelin B-succinate from the terrestrial myxobacterial strain MSr12020, featuring a succinyl decoration at its primary amine group. Myxochelin-B-succinate exhibited antibacterial growth inhibition and moderate cytotoxic activity against selected human cancer cell lines. This unique chemical modification of myxochelin B might provide interesting insights for future microbiological studies to understand the biological function and biosynthesis of secondary metabolite succinylation. |
| first_indexed | 2024-03-09T19:45:45Z |
| format | Article |
| id | doaj.art-ced5ff7f0f4445b3b95606c9ed2c5e3c |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T19:45:45Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-ced5ff7f0f4445b3b95606c9ed2c5e3c2023-11-24T01:26:06ZengMDPI AGMicroorganisms2076-26072022-09-011010195910.3390/microorganisms10101959Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020Dorothy A. Okoth0Joachim J. Hug1Ronald Garcia2Rolf Müller3Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Microbial Natural Products, Campus E8 1, Saarland University, 66123 Saarbrücken, GermanyHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Microbial Natural Products, Campus E8 1, Saarland University, 66123 Saarbrücken, GermanyHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Microbial Natural Products, Campus E8 1, Saarland University, 66123 Saarbrücken, GermanyHelmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Department of Microbial Natural Products, Campus E8 1, Saarland University, 66123 Saarbrücken, GermanyMyxobacteria feature unique biological characteristics, including their capability to glide on the surface, undergo different multicellular developmental stages and produce structurally unique natural products such as the catecholate-type siderophores myxochelins A and B. Herein, we report the isolation, structure elucidation and a proposed biosynthesis of the new congener myxochelin B-succinate from the terrestrial myxobacterial strain MSr12020, featuring a succinyl decoration at its primary amine group. Myxochelin-B-succinate exhibited antibacterial growth inhibition and moderate cytotoxic activity against selected human cancer cell lines. This unique chemical modification of myxochelin B might provide interesting insights for future microbiological studies to understand the biological function and biosynthesis of secondary metabolite succinylation.https://www.mdpi.com/2076-2607/10/10/1959myxochelinmyxobacteriabiosynthesisnatural productssecondary metabolitessuccinylation |
| spellingShingle | Dorothy A. Okoth Joachim J. Hug Ronald Garcia Rolf Müller Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020 Microorganisms myxochelin myxobacteria biosynthesis natural products secondary metabolites succinylation |
| title | Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020 |
| title_full | Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020 |
| title_fullStr | Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020 |
| title_full_unstemmed | Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020 |
| title_short | Discovery, Biosynthesis and Biological Activity of a Succinylated Myxochelin from the Myxobacterial Strain MSr12020 |
| title_sort | discovery biosynthesis and biological activity of a succinylated myxochelin from the myxobacterial strain msr12020 |
| topic | myxochelin myxobacteria biosynthesis natural products secondary metabolites succinylation |
| url | https://www.mdpi.com/2076-2607/10/10/1959 |
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