Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits

Acute colitis during chronic experimental traumatic brain injury in mice induces dysautonomia and persistent extraintestinal, systemic, and CNS inflammation with exacerbated neurological deficits

Abstract Background Disruptions of brain-gut axis have been implicated in the progression of a variety of gastrointestinal (GI) disorders and central nervous system (CNS) diseases and injuries, including traumatic brain injury (TBI). TBI is a chronic disease process characterized by persistent secon...

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Bibliographic Details
Main Authors: Marie Hanscom, David J. Loane, Taryn Aubretch, Jenna Leser, Kara Molesworth, Nivedita Hedgekar, Rodney M. Ritzel, Gelareh Abulwerdi, Terez Shea-Donohue, Alan I. Faden
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Neuroinflammation
Subjects:
TBI
DSS
Colitis
Neuroinflammation
Neurodegeneration
Neurobehavior
Online Access:https://doi.org/10.1186/s12974-020-02067-x

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