Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film
In the present study, the piezoelectric aluminum nitride (AlN)/tantalum (Ta) (PAT) thin film was investigated as a biocompatible film and osseointegrated with biomedical devices such as implants. The stress variation on the interaction of cells with the PAT surface was investigated using osteoblast-...
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MDPI AG
2020-01-01
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author | Mao-Suan Huang Shang-Yang Yu Pao-Chang Chiang Bai-Hung Huang Takashi Saito Chien-Chia Huang Fang-Tzu Pai Chia-Yu Wu Wen-Chien Lan |
author_facet | Mao-Suan Huang Shang-Yang Yu Pao-Chang Chiang Bai-Hung Huang Takashi Saito Chien-Chia Huang Fang-Tzu Pai Chia-Yu Wu Wen-Chien Lan |
author_sort | Mao-Suan Huang |
collection | DOAJ |
description | In the present study, the piezoelectric aluminum nitride (AlN)/tantalum (Ta) (PAT) thin film was investigated as a biocompatible film and osseointegrated with biomedical devices such as implants. The stress variation on the interaction of cells with the PAT surface was investigated using osteoblast-like cells (MG-63) and fibroblast cells (NIH3T3). A singular behavior was observed on the PAT film with a (002) texture, in which the MG-63 cells were more dispersed and displayed longer and more filopodia than the NIH3T3 cells. Moreover, the MG-63 cells showed ingrowth, adherence, and proliferation on the PAT film surface. The MG-63 cells had more obvious stress variation than the NIH3T3 cells in the differentiation and proliferation. The mechanobiological reaction to cell differentiation and proliferation not only caused osseointegration, but also reduced the surface activation energy, thus enhancing bone remodeling. The formation of a nanopolycrystalline PAT film is believed to enhance the mechanobiological effect, promoting osseointegration. |
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language | English |
last_indexed | 2024-04-13T06:17:34Z |
publishDate | 2020-01-01 |
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series | Applied Sciences |
spelling | doaj.art-ceda1be0df184768865a81db365becf22022-12-22T02:58:46ZengMDPI AGApplied Sciences2076-34172020-01-0110264510.3390/app10020645app10020645Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin FilmMao-Suan Huang0Shang-Yang Yu1Pao-Chang Chiang2Bai-Hung Huang3Takashi Saito4Chien-Chia Huang5Fang-Tzu Pai6Chia-Yu Wu7Wen-Chien Lan8Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, TaiwanDepartment of Dentistry, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanAsia Pacific Laser Institute, New Taipei City 220, TaiwanDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, JapanDivision of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido 061-0293, JapanSchool of Dental Technology, Taipei Medical University, Taipei 110, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Oral Hygiene Care, Ching Kuo Institute of Management and Health, Keelung 203, TaiwanIn the present study, the piezoelectric aluminum nitride (AlN)/tantalum (Ta) (PAT) thin film was investigated as a biocompatible film and osseointegrated with biomedical devices such as implants. The stress variation on the interaction of cells with the PAT surface was investigated using osteoblast-like cells (MG-63) and fibroblast cells (NIH3T3). A singular behavior was observed on the PAT film with a (002) texture, in which the MG-63 cells were more dispersed and displayed longer and more filopodia than the NIH3T3 cells. Moreover, the MG-63 cells showed ingrowth, adherence, and proliferation on the PAT film surface. The MG-63 cells had more obvious stress variation than the NIH3T3 cells in the differentiation and proliferation. The mechanobiological reaction to cell differentiation and proliferation not only caused osseointegration, but also reduced the surface activation energy, thus enhancing bone remodeling. The formation of a nanopolycrystalline PAT film is believed to enhance the mechanobiological effect, promoting osseointegration.https://www.mdpi.com/2076-3417/10/2/645aluminum nitridepiezoelectric filmmechanobiological effectstress variation |
spellingShingle | Mao-Suan Huang Shang-Yang Yu Pao-Chang Chiang Bai-Hung Huang Takashi Saito Chien-Chia Huang Fang-Tzu Pai Chia-Yu Wu Wen-Chien Lan Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film Applied Sciences aluminum nitride piezoelectric film mechanobiological effect stress variation |
title | Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film |
title_full | Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film |
title_fullStr | Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film |
title_full_unstemmed | Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film |
title_short | Effect of Mechanobiology of Cell Response on Titanium with Multilayered Aluminum Nitride/Tantalum Thin Film |
title_sort | effect of mechanobiology of cell response on titanium with multilayered aluminum nitride tantalum thin film |
topic | aluminum nitride piezoelectric film mechanobiological effect stress variation |
url | https://www.mdpi.com/2076-3417/10/2/645 |
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