Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers
Post-traumatic stress disorder (PTSD) is a complex psychological disorder that develops following exposure to traumatic events. PTSD is influenced by catalytic factors such as dysregulated hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter imbalances, and oxidative stress. Genetic variation...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Biology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-7737/12/8/1050 |
| _version_ | 1797436023155720192 |
|---|---|
| author | Konstantina Skolariki Aristidis G. Vrahatis Marios G. Krokidis Themis P. Exarchos Panagiotis Vlamos |
| author_facet | Konstantina Skolariki Aristidis G. Vrahatis Marios G. Krokidis Themis P. Exarchos Panagiotis Vlamos |
| author_sort | Konstantina Skolariki |
| collection | DOAJ |
| description | Post-traumatic stress disorder (PTSD) is a complex psychological disorder that develops following exposure to traumatic events. PTSD is influenced by catalytic factors such as dysregulated hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter imbalances, and oxidative stress. Genetic variations may act as important catalysts, impacting neurochemical signaling, synaptic plasticity, and stress response systems. Understanding the intricate gene networks and their interactions is vital for comprehending the underlying mechanisms of PTSD. Focusing on the catalytic factors of PTSD is essential because they provide valuable insights into the underlying mechanisms of the disorder. By understanding these factors and their interplay, researchers may uncover potential targets for interventions and therapies, leading to more effective and personalized treatments for individuals with PTSD. The aforementioned gene networks, composed of specific genes associated with the disorder, provide a comprehensive view of the molecular pathways and regulatory mechanisms involved in PTSD. Through this study valuable insights into the disorder’s underlying mechanisms and opening avenues for effective treatments, personalized interventions, and the development of biomarkers for early detection and monitoring are provided. |
| first_indexed | 2024-03-09T10:56:40Z |
| format | Article |
| id | doaj.art-ceda5f9b732d461898c4b30061a7aef0 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T10:56:40Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-ceda5f9b732d461898c4b30061a7aef02023-12-01T01:37:43ZengMDPI AGBiology2079-77372023-07-01128105010.3390/biology12081050Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional BiomarkersKonstantina Skolariki0Aristidis G. Vrahatis1Marios G. Krokidis2Themis P. Exarchos3Panagiotis Vlamos4Bioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, GreeceBioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, GreeceBioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, GreeceBioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, GreeceBioinformatics and Human Electrophysiology Laboratory, Department of Informatics, Ionian University, 49100 Corfu, GreecePost-traumatic stress disorder (PTSD) is a complex psychological disorder that develops following exposure to traumatic events. PTSD is influenced by catalytic factors such as dysregulated hypothalamic-pituitary-adrenal (HPA) axis, neurotransmitter imbalances, and oxidative stress. Genetic variations may act as important catalysts, impacting neurochemical signaling, synaptic plasticity, and stress response systems. Understanding the intricate gene networks and their interactions is vital for comprehending the underlying mechanisms of PTSD. Focusing on the catalytic factors of PTSD is essential because they provide valuable insights into the underlying mechanisms of the disorder. By understanding these factors and their interplay, researchers may uncover potential targets for interventions and therapies, leading to more effective and personalized treatments for individuals with PTSD. The aforementioned gene networks, composed of specific genes associated with the disorder, provide a comprehensive view of the molecular pathways and regulatory mechanisms involved in PTSD. Through this study valuable insights into the disorder’s underlying mechanisms and opening avenues for effective treatments, personalized interventions, and the development of biomarkers for early detection and monitoring are provided.https://www.mdpi.com/2079-7737/12/8/1050post-traumatic stress disorderbiomarkersneurotransmitter imbalancehypothalamic-pituitary-adrenal axisnetwork analysis |
| spellingShingle | Konstantina Skolariki Aristidis G. Vrahatis Marios G. Krokidis Themis P. Exarchos Panagiotis Vlamos Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers Biology post-traumatic stress disorder biomarkers neurotransmitter imbalance hypothalamic-pituitary-adrenal axis network analysis |
| title | Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers |
| title_full | Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers |
| title_fullStr | Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers |
| title_full_unstemmed | Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers |
| title_short | Assessing and Modelling of Post-Traumatic Stress Disorder Using Molecular and Functional Biomarkers |
| title_sort | assessing and modelling of post traumatic stress disorder using molecular and functional biomarkers |
| topic | post-traumatic stress disorder biomarkers neurotransmitter imbalance hypothalamic-pituitary-adrenal axis network analysis |
| url | https://www.mdpi.com/2079-7737/12/8/1050 |
| work_keys_str_mv | AT konstantinaskolariki assessingandmodellingofposttraumaticstressdisorderusingmolecularandfunctionalbiomarkers AT aristidisgvrahatis assessingandmodellingofposttraumaticstressdisorderusingmolecularandfunctionalbiomarkers AT mariosgkrokidis assessingandmodellingofposttraumaticstressdisorderusingmolecularandfunctionalbiomarkers AT themispexarchos assessingandmodellingofposttraumaticstressdisorderusingmolecularandfunctionalbiomarkers AT panagiotisvlamos assessingandmodellingofposttraumaticstressdisorderusingmolecularandfunctionalbiomarkers |