Platelets and Immune Responses During Thromboinflammation
Besides mediating hemostatic functions, platelets are increasingly recognized as important players of inflammation. Data from experiments in mice and men revealed various intersection points between thrombosis, hemostasis, and inflammation, which are addressed and discussed in this review in detail....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.01731/full |
| _version_ | 1828746602867589120 |
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| author | Matthias Mezger Henry Nording Henry Nording Reinhard Sauter Tobias Graf Christian Heim Nikolas von Bubnoff Stephan M. Ensminger Harald F. Langer Harald F. Langer |
| author_facet | Matthias Mezger Henry Nording Henry Nording Reinhard Sauter Tobias Graf Christian Heim Nikolas von Bubnoff Stephan M. Ensminger Harald F. Langer Harald F. Langer |
| author_sort | Matthias Mezger |
| collection | DOAJ |
| description | Besides mediating hemostatic functions, platelets are increasingly recognized as important players of inflammation. Data from experiments in mice and men revealed various intersection points between thrombosis, hemostasis, and inflammation, which are addressed and discussed in this review in detail. One such example is the intrinsic coagulation cascade that is initiated after platelet activation thereby further propagating and re-enforcing wound healing or thrombus formation but also contributing to the pathophysiology of severe diseases. FXII of the intrinsic pathway connects platelet activation with the coagulation cascade during immune reactions. It can activate the contact system thereby either creating an inflammatory state or accelerating inflammation. Recent insights into platelet biology could show that platelets are equipped with complement receptors. Platelets are important for tissue remodeling after injury has been inflicted to the endothelial barrier and to the subendothelial tissue. Thus, platelets are increasingly recognized as more than just cells relevant for bleeding arrest. Future insights into platelet biology are to be expected. This research will potentially offer novel opportunities for therapeutic intervention in diseases featuring platelet abundance. |
| first_indexed | 2024-04-14T04:27:46Z |
| format | Article |
| id | doaj.art-cedb15f843bd4a4395ed325bbe05c4be |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T04:27:46Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cedb15f843bd4a4395ed325bbe05c4be2022-12-22T02:12:13ZengFrontiers Media S.A.Frontiers in Immunology1664-32242019-07-011010.3389/fimmu.2019.01731460334Platelets and Immune Responses During ThromboinflammationMatthias Mezger0Henry Nording1Henry Nording2Reinhard Sauter3Tobias Graf4Christian Heim5Nikolas von Bubnoff6Stephan M. Ensminger7Harald F. Langer8Harald F. Langer9University Hospital, Medical Clinic II, University Heart Center Lübeck, Lübeck, GermanyUniversity Hospital, Medical Clinic II, University Heart Center Lübeck, Lübeck, GermanyDZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, Lübeck, GermanyUniversity Hospital, Medical Clinic II, University Heart Center Lübeck, Lübeck, GermanyUniversity Hospital, Medical Clinic II, University Heart Center Lübeck, Lübeck, GermanyDepartment of Cardiac Surgery, University Hospital Erlangen, Erlangen, GermanyDepartment of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, GermanyDepartment of Cardiac and Thoracic Vascular Surgery, University Heart Center Lübeck, Lübeck, GermanyUniversity Hospital, Medical Clinic II, University Heart Center Lübeck, Lübeck, GermanyDZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, Lübeck, GermanyBesides mediating hemostatic functions, platelets are increasingly recognized as important players of inflammation. Data from experiments in mice and men revealed various intersection points between thrombosis, hemostasis, and inflammation, which are addressed and discussed in this review in detail. One such example is the intrinsic coagulation cascade that is initiated after platelet activation thereby further propagating and re-enforcing wound healing or thrombus formation but also contributing to the pathophysiology of severe diseases. FXII of the intrinsic pathway connects platelet activation with the coagulation cascade during immune reactions. It can activate the contact system thereby either creating an inflammatory state or accelerating inflammation. Recent insights into platelet biology could show that platelets are equipped with complement receptors. Platelets are important for tissue remodeling after injury has been inflicted to the endothelial barrier and to the subendothelial tissue. Thus, platelets are increasingly recognized as more than just cells relevant for bleeding arrest. Future insights into platelet biology are to be expected. This research will potentially offer novel opportunities for therapeutic intervention in diseases featuring platelet abundance.https://www.frontiersin.org/article/10.3389/fimmu.2019.01731/fullplateletsinnate immunitycomplementinflammationstrokeinfection |
| spellingShingle | Matthias Mezger Henry Nording Henry Nording Reinhard Sauter Tobias Graf Christian Heim Nikolas von Bubnoff Stephan M. Ensminger Harald F. Langer Harald F. Langer Platelets and Immune Responses During Thromboinflammation Frontiers in Immunology platelets innate immunity complement inflammation stroke infection |
| title | Platelets and Immune Responses During Thromboinflammation |
| title_full | Platelets and Immune Responses During Thromboinflammation |
| title_fullStr | Platelets and Immune Responses During Thromboinflammation |
| title_full_unstemmed | Platelets and Immune Responses During Thromboinflammation |
| title_short | Platelets and Immune Responses During Thromboinflammation |
| title_sort | platelets and immune responses during thromboinflammation |
| topic | platelets innate immunity complement inflammation stroke infection |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.01731/full |
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