Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice

Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice

Myelodysplastic syndrome (MDS) is a heterogeneous group of bone marrow stem cell disorders characterized by ineffective hematopoiesis and cytopenias, most commonly anemia. Red cell transfusion therapy for anemia in MDS results in iron overload, correlating with reduced overall survival. Whether the...

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Bibliographic Details
Main Authors: Wenbin An, Maria Feola, Maayan Levy, Srinivas Aluri, Marc Ruiz-Martinez, Ashwin Sridharan, Eitan Fibach, Xiaofan Zhu, Amit Verma, Yelena Ginzburg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-12-01
Series:eLife
Subjects:
myelodysplastic dyndrome
deferiprone
ineffective erythropoiesis
iron trafficking
Online Access:https://elifesciences.org/articles/83103

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