Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies
The multi-faceted nature of functionalized magnetic nanoparticles (fMNPs) is well-suited for cancer therapy. These nanocomposites can also provide a multimodal platform for targeted cancer therapy due to their unique magnetic guidance characteristics. When induced by an alternating magnetic field (A...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/8/1279 |
| _version_ | 1827599058350374912 |
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| author | Anilkumar Thaghalli Shivanna Banendu Sunder Dash Jyh-Ping Chen |
| author_facet | Anilkumar Thaghalli Shivanna Banendu Sunder Dash Jyh-Ping Chen |
| author_sort | Anilkumar Thaghalli Shivanna |
| collection | DOAJ |
| description | The multi-faceted nature of functionalized magnetic nanoparticles (fMNPs) is well-suited for cancer therapy. These nanocomposites can also provide a multimodal platform for targeted cancer therapy due to their unique magnetic guidance characteristics. When induced by an alternating magnetic field (AMF), fMNPs can convert the magnetostatic energy to heat for magnetic hyperthermia (MHT), as well as for controlled drug release. Furthermore, with the ability to convert near-infrared (NIR) light energy to heat energy, fMNPs have attracted interest for photothermal therapy (PTT). Other than MHT and PTT, fMNPs also have a place in combination cancer therapies, such as chemo-MHT, chemo-PTT, and chemo-PTT–photodynamic therapy, among others, due to their versatile properties. Thus, this review presents multifunctional nanocomposites based on fMNPs for cancer therapies, induced by an AMF or NIR light. We will first discuss the different fMNPs induced with an AMF for cancer MHT and chemo-MHT. Secondly, we will discuss fMNPs irradiated with NIR lasers for cancer PTT and chemo-PTT. Finally, fMNPs used for dual-mode AMF + NIR-laser-induced magneto-photo-hyperthermia (MPHT) will be discussed. |
| first_indexed | 2024-03-09T04:04:58Z |
| format | Article |
| id | doaj.art-cedca7419d5b414397a4fddd5e63f809 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T04:04:58Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-cedca7419d5b414397a4fddd5e63f8092023-12-03T14:08:08ZengMDPI AGMicromachines2072-666X2022-08-01138127910.3390/mi13081279Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer TherapiesAnilkumar Thaghalli Shivanna0Banendu Sunder Dash1Jyh-Ping Chen2Department of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 33302, TaiwanDepartment of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 33302, TaiwanDepartment of Chemical and Materials Engineering, Chang Gung University, Kwei-San, Taoyuan 33302, TaiwanThe multi-faceted nature of functionalized magnetic nanoparticles (fMNPs) is well-suited for cancer therapy. These nanocomposites can also provide a multimodal platform for targeted cancer therapy due to their unique magnetic guidance characteristics. When induced by an alternating magnetic field (AMF), fMNPs can convert the magnetostatic energy to heat for magnetic hyperthermia (MHT), as well as for controlled drug release. Furthermore, with the ability to convert near-infrared (NIR) light energy to heat energy, fMNPs have attracted interest for photothermal therapy (PTT). Other than MHT and PTT, fMNPs also have a place in combination cancer therapies, such as chemo-MHT, chemo-PTT, and chemo-PTT–photodynamic therapy, among others, due to their versatile properties. Thus, this review presents multifunctional nanocomposites based on fMNPs for cancer therapies, induced by an AMF or NIR light. We will first discuss the different fMNPs induced with an AMF for cancer MHT and chemo-MHT. Secondly, we will discuss fMNPs irradiated with NIR lasers for cancer PTT and chemo-PTT. Finally, fMNPs used for dual-mode AMF + NIR-laser-induced magneto-photo-hyperthermia (MPHT) will be discussed.https://www.mdpi.com/2072-666X/13/8/1279magnetic nanoparticlesmagnetic hyperthermiaphotothermal therapymagnetic targetingalternating magnetic fieldnear-infrared |
| spellingShingle | Anilkumar Thaghalli Shivanna Banendu Sunder Dash Jyh-Ping Chen Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies Micromachines magnetic nanoparticles magnetic hyperthermia photothermal therapy magnetic targeting alternating magnetic field near-infrared |
| title | Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies |
| title_full | Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies |
| title_fullStr | Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies |
| title_full_unstemmed | Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies |
| title_short | Functionalized Magnetic Nanoparticles for Alternating Magnetic Field- or Near Infrared Light-Induced Cancer Therapies |
| title_sort | functionalized magnetic nanoparticles for alternating magnetic field or near infrared light induced cancer therapies |
| topic | magnetic nanoparticles magnetic hyperthermia photothermal therapy magnetic targeting alternating magnetic field near-infrared |
| url | https://www.mdpi.com/2072-666X/13/8/1279 |
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