Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum?
Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases a...
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| Format: | Article |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2021.767201/full |
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| author | Chih-Huang Tseng Chih-Huang Tseng Chih-Huang Tseng Pei-Hsuan Lu Pei-Hsuan Lu Yi-Ping Wang Yi-Ping Wang Yi-Ping Wang Chun-Pin Chiang Chun-Pin Chiang Yi-Shing Lisa Cheng Julia Yu Fong Chang Julia Yu Fong Chang Julia Yu Fong Chang |
| author_facet | Chih-Huang Tseng Chih-Huang Tseng Chih-Huang Tseng Pei-Hsuan Lu Pei-Hsuan Lu Yi-Ping Wang Yi-Ping Wang Yi-Ping Wang Chun-Pin Chiang Chun-Pin Chiang Yi-Shing Lisa Cheng Julia Yu Fong Chang Julia Yu Fong Chang Julia Yu Fong Chang |
| author_sort | Chih-Huang Tseng |
| collection | DOAJ |
| description | Overlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases are indeed one unique disease entity or belong to CEOT and COF, respectively. To clarify this issue, we have performed a literature review to compare the similarities and differences in clinicopathological features among NCLC-CEOT, AR-COF, classic CEOT, and classic COF. We aimed to investigate whether NCLC-CEOT and AR-COF might be the same and one distinctive disease entity, or a variant (or variants) of either CEOT or COF; or whether COF, NCLC-CEOT/AR-COF, and CEOT represented a histopathological spectrum of one disease. Our results indicate that NCLC-CEOT and AR-COF cases share many similar clinicopathological features. Thus, we suggest that they are the same disease entity. Due to nearly no reported recurrence of NCLC-CEOT/AR-COF cases, the conservative surgical treatment is appropriate. The NCLC-CEOT/AR-COF cases show some overlapping clinicopathological features with COF rather than the CEOT cases. However, differences in the clinicopathological features are still recognized among the NCLC-CEOT/AR-COF, COF, and CEOT cases. Future research, particularly molecular biological studies, may further elucidate their relationships and assist proper classification of the NCLC-CEOT/AR-COF cases. |
| first_indexed | 2024-12-19T03:32:11Z |
| format | Article |
| id | doaj.art-cedcc309eeff4f40bbd63ac8d9f6a491 |
| institution | Directory Open Access Journal |
| issn | 2673-4842 |
| language | English |
| last_indexed | 2024-12-19T03:32:11Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj.art-cedcc309eeff4f40bbd63ac8d9f6a4912022-12-21T20:37:29ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422021-10-01210.3389/froh.2021.767201767201Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum?Chih-Huang Tseng0Chih-Huang Tseng1Chih-Huang Tseng2Pei-Hsuan Lu3Pei-Hsuan Lu4Yi-Ping Wang5Yi-Ping Wang6Yi-Ping Wang7Chun-Pin Chiang8Chun-Pin Chiang9Yi-Shing Lisa Cheng10Julia Yu Fong Chang11Julia Yu Fong Chang12Julia Yu Fong Chang13Division of Oral Pathology and Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanOral and Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, TaiwanDepartment of Diagnostic Sciences, Texas A&M University College of Dentistry, Dallas, TX, United StatesGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanDepartment of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, TaiwanGraduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanOverlapping clinicopathological features of non-calcifying Langerhans cell rich variant of calcifying epithelial odontogenic tumor (NCLC-CEOT) and the amyloid rich variant of the central odontogenic fibroma (AR-COF) have been recognized recently. It is still under debate whether these two diseases are indeed one unique disease entity or belong to CEOT and COF, respectively. To clarify this issue, we have performed a literature review to compare the similarities and differences in clinicopathological features among NCLC-CEOT, AR-COF, classic CEOT, and classic COF. We aimed to investigate whether NCLC-CEOT and AR-COF might be the same and one distinctive disease entity, or a variant (or variants) of either CEOT or COF; or whether COF, NCLC-CEOT/AR-COF, and CEOT represented a histopathological spectrum of one disease. Our results indicate that NCLC-CEOT and AR-COF cases share many similar clinicopathological features. Thus, we suggest that they are the same disease entity. Due to nearly no reported recurrence of NCLC-CEOT/AR-COF cases, the conservative surgical treatment is appropriate. The NCLC-CEOT/AR-COF cases show some overlapping clinicopathological features with COF rather than the CEOT cases. However, differences in the clinicopathological features are still recognized among the NCLC-CEOT/AR-COF, COF, and CEOT cases. Future research, particularly molecular biological studies, may further elucidate their relationships and assist proper classification of the NCLC-CEOT/AR-COF cases.https://www.frontiersin.org/articles/10.3389/froh.2021.767201/fullodontogenic tumorcalcifying epithelial odontogenic tumorcentral odontogenic fibromanon-calcifying Langerhans cell rich variant CEOTamyloid rich variant central odontogenic fibroma |
| spellingShingle | Chih-Huang Tseng Chih-Huang Tseng Chih-Huang Tseng Pei-Hsuan Lu Pei-Hsuan Lu Yi-Ping Wang Yi-Ping Wang Yi-Ping Wang Chun-Pin Chiang Chun-Pin Chiang Yi-Shing Lisa Cheng Julia Yu Fong Chang Julia Yu Fong Chang Julia Yu Fong Chang Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum? Frontiers in Oral Health odontogenic tumor calcifying epithelial odontogenic tumor central odontogenic fibroma non-calcifying Langerhans cell rich variant CEOT amyloid rich variant central odontogenic fibroma |
| title | Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum? |
| title_full | Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum? |
| title_fullStr | Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum? |
| title_full_unstemmed | Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum? |
| title_short | Non-calcifying Langerhans Cell Rich Variant of Calcifying Epithelial Odontogenic Tumor and Amyloid Rich Variant of Central Odontogenic Fibroma: A Unique Entity or a Spectrum? |
| title_sort | non calcifying langerhans cell rich variant of calcifying epithelial odontogenic tumor and amyloid rich variant of central odontogenic fibroma a unique entity or a spectrum |
| topic | odontogenic tumor calcifying epithelial odontogenic tumor central odontogenic fibroma non-calcifying Langerhans cell rich variant CEOT amyloid rich variant central odontogenic fibroma |
| url | https://www.frontiersin.org/articles/10.3389/froh.2021.767201/full |
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