Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation
Plants and fungi can be used for medical applications because of their accumulation of special bioactive metabolites. These substances might be beneficial to human health, exerting also anti-inflammatory and anticancer (antiproliferative) effects. We propose that they are mediated by influencing cel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/12/1781 |
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| author | Beatrix Péter Imre Boldizsár Gábor M. Kovács Anna Erdei Zsuzsa Bajtay Alexandra Vörös Jeremy J. Ramsden Ildikó Szabó Szilvia Bősze Robert Horvath |
| author_facet | Beatrix Péter Imre Boldizsár Gábor M. Kovács Anna Erdei Zsuzsa Bajtay Alexandra Vörös Jeremy J. Ramsden Ildikó Szabó Szilvia Bősze Robert Horvath |
| author_sort | Beatrix Péter |
| collection | DOAJ |
| description | Plants and fungi can be used for medical applications because of their accumulation of special bioactive metabolites. These substances might be beneficial to human health, exerting also anti-inflammatory and anticancer (antiproliferative) effects. We propose that they are mediated by influencing cellular adhesion and migration via various signaling pathways and by directly inactivating key cell adhesion surface receptor sites. The evidence for this proposition is reviewed (by summarizing the natural metabolites and their effects influencing cellular adhesion and migration), along with the classical measuring techniques used to gain such evidence. We systematize existing knowledge concerning the mechanisms of how natural metabolites affect adhesion and movement, and their role in gene expression as well. We conclude by highlighting the possibilities to screen natural compounds faster and more easily by applying new label-free methods, which also enable a far greater degree of quantification than the conventional methods used hitherto. We have systematically classified recent studies regarding the effects of natural compounds on cellular adhesion and movement, characterizing the active substances according to their organismal origin (plants, animals or fungi). Finally, we also summarize the results of recent studies and experiments on SARS-CoV-2 treatments by natural extracts affecting mainly the adhesion and entry of the virus. |
| first_indexed | 2024-03-10T04:34:07Z |
| format | Article |
| id | doaj.art-ceddf9f20cb046c9bee63b552f3e6ea4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T04:34:07Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ceddf9f20cb046c9bee63b552f3e6ea42023-11-23T03:55:28ZengMDPI AGBiomedicines2227-90592021-11-01912178110.3390/biomedicines9121781Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based IsolationBeatrix Péter0Imre Boldizsár1Gábor M. Kovács2Anna Erdei3Zsuzsa Bajtay4Alexandra Vörös5Jeremy J. Ramsden6Ildikó Szabó7Szilvia Bősze8Robert Horvath9Nanobiosensorics Group, Research Centre for Energy Research, Institute for Technical Physics and Materials Science, Konkoly-Thege u 29-33, 1120 Budapest, HungaryDepartment of Plant Anatomy, Institute of Biology, Eötvös Loránd University, 1117 Budapest, HungaryDepartment of Plant Anatomy, Institute of Biology, Eötvös Loránd University, 1117 Budapest, HungaryDepartment of Immunology, Eötvös Loránd University, 1117 Budapest, HungaryDepartment of Immunology, Eötvös Loránd University, 1117 Budapest, HungaryNanobiosensorics Group, Research Centre for Energy Research, Institute for Technical Physics and Materials Science, Konkoly-Thege u 29-33, 1120 Budapest, HungaryClore Laboratory, University of Buckingham, Buckingham MK18 1EG, UKMTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd Research Network (ELKH), Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, HungaryMTA-ELTE Research Group of Peptide Chemistry, Eötvös Loránd Research Network (ELKH), Institute of Chemistry, Eötvös Loránd University, 1117 Budapest, HungaryNanobiosensorics Group, Research Centre for Energy Research, Institute for Technical Physics and Materials Science, Konkoly-Thege u 29-33, 1120 Budapest, HungaryPlants and fungi can be used for medical applications because of their accumulation of special bioactive metabolites. These substances might be beneficial to human health, exerting also anti-inflammatory and anticancer (antiproliferative) effects. We propose that they are mediated by influencing cellular adhesion and migration via various signaling pathways and by directly inactivating key cell adhesion surface receptor sites. The evidence for this proposition is reviewed (by summarizing the natural metabolites and their effects influencing cellular adhesion and migration), along with the classical measuring techniques used to gain such evidence. We systematize existing knowledge concerning the mechanisms of how natural metabolites affect adhesion and movement, and their role in gene expression as well. We conclude by highlighting the possibilities to screen natural compounds faster and more easily by applying new label-free methods, which also enable a far greater degree of quantification than the conventional methods used hitherto. We have systematically classified recent studies regarding the effects of natural compounds on cellular adhesion and movement, characterizing the active substances according to their organismal origin (plants, animals or fungi). Finally, we also summarize the results of recent studies and experiments on SARS-CoV-2 treatments by natural extracts affecting mainly the adhesion and entry of the virus.https://www.mdpi.com/2227-9059/9/12/1781natural compoundcell adhesionmovementCAMintegrinviability |
| spellingShingle | Beatrix Péter Imre Boldizsár Gábor M. Kovács Anna Erdei Zsuzsa Bajtay Alexandra Vörös Jeremy J. Ramsden Ildikó Szabó Szilvia Bősze Robert Horvath Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation Biomedicines natural compound cell adhesion movement CAM integrin viability |
| title | Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation |
| title_full | Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation |
| title_fullStr | Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation |
| title_full_unstemmed | Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation |
| title_short | Natural Compounds as Target Biomolecules in Cellular Adhesion and Migration: From Biomolecular Stimulation to Label-Free Discovery and Bioactivity-Based Isolation |
| title_sort | natural compounds as target biomolecules in cellular adhesion and migration from biomolecular stimulation to label free discovery and bioactivity based isolation |
| topic | natural compound cell adhesion movement CAM integrin viability |
| url | https://www.mdpi.com/2227-9059/9/12/1781 |
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