Direct and Indirect Timing Functions in Unilateral Hemispheric Lesion
Introduction: The neural substrates of temporal processing are not still fully known. The majority of interval timing studies have dealt with this subject in the context of “Explicit timing” (computing the time intervals explicitly). The hypothesis “Implicit timing” (implicitly using temporal proces...
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| Format: | Article |
| Language: | English |
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Iran University of Medical Sciences
2020-05-01
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| Series: | Basic and Clinical Neuroscience |
| Subjects: | |
| Online Access: | http://bcn.iums.ac.ir/article-1-1125-en.html |
| _version_ | 1797282520671191040 |
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| author | Ali Hosseini Sajjad Rezaei Alia Saberi |
| author_facet | Ali Hosseini Sajjad Rezaei Alia Saberi |
| author_sort | Ali Hosseini |
| collection | DOAJ |
| description | Introduction: The neural substrates of temporal processing are not still fully known. The majority of interval timing studies have dealt with this subject in the context of “Explicit timing” (computing the time intervals explicitly). The hypothesis “Implicit timing” (implicitly using temporal processing to improve function) has also proposed. This lesion study addressed explicit and implicit timing paradigms simultaneously using identical experimental tasks.
Methods: In this case-control study, 15 patients with Right Hemisphere Damage (RHD) and 15 patients with Left Hemisphere Damage (LHD) and 15 age-matched normal subjects were included. Participants performed a temporal reproduction task (assessing explicit timing) and a temporal prediction task (assessing implicit timing) in two sub- and supra-second intervals.
Results: Our results showed that RHD can lead to significantly lower accuracy in the temporal reproduction task in sub-second (p=0.005) and supra-second (p=0.001) intervals, compared with the normal subjects. Also, LHD led to perturbation in temporal prediction task by an increase in reaction time (lower accuracy) in sub- (p=0.011) and supra-second (p=0.006) time intervals than the normal subjects.
Conclusion: Overall, our findings suggested that there is a right hemispheric bias in the neural substrate of explicit timing, in both sub- and supra-second intervals. Furthermore, for the first time in a lesion study, we showed the evidence of left-hemispheric bias in neural substrates of implicit timing. |
| first_indexed | 2024-03-07T17:15:13Z |
| format | Article |
| id | doaj.art-cede970340d04567b2615008b326cb1f |
| institution | Directory Open Access Journal |
| issn | 2008-126X 2228-7442 |
| language | English |
| last_indexed | 2024-03-07T17:15:13Z |
| publishDate | 2020-05-01 |
| publisher | Iran University of Medical Sciences |
| record_format | Article |
| series | Basic and Clinical Neuroscience |
| spelling | doaj.art-cede970340d04567b2615008b326cb1f2024-03-02T23:28:20ZengIran University of Medical SciencesBasic and Clinical Neuroscience2008-126X2228-74422020-05-01113301312Direct and Indirect Timing Functions in Unilateral Hemispheric LesionAli Hosseini0Sajjad Rezaei1Alia Saberi2 Department of Biomedical Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Universiteitsplein, Antwerp, Belgium. Department of Psychology, Faculty of Literature and Humanities, University of Guilan, Rasht, Iran. eurosciences Research Center, Neurology Department, Pouursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Introduction: The neural substrates of temporal processing are not still fully known. The majority of interval timing studies have dealt with this subject in the context of “Explicit timing” (computing the time intervals explicitly). The hypothesis “Implicit timing” (implicitly using temporal processing to improve function) has also proposed. This lesion study addressed explicit and implicit timing paradigms simultaneously using identical experimental tasks. Methods: In this case-control study, 15 patients with Right Hemisphere Damage (RHD) and 15 patients with Left Hemisphere Damage (LHD) and 15 age-matched normal subjects were included. Participants performed a temporal reproduction task (assessing explicit timing) and a temporal prediction task (assessing implicit timing) in two sub- and supra-second intervals. Results: Our results showed that RHD can lead to significantly lower accuracy in the temporal reproduction task in sub-second (p=0.005) and supra-second (p=0.001) intervals, compared with the normal subjects. Also, LHD led to perturbation in temporal prediction task by an increase in reaction time (lower accuracy) in sub- (p=0.011) and supra-second (p=0.006) time intervals than the normal subjects. Conclusion: Overall, our findings suggested that there is a right hemispheric bias in the neural substrate of explicit timing, in both sub- and supra-second intervals. Furthermore, for the first time in a lesion study, we showed the evidence of left-hemispheric bias in neural substrates of implicit timing.http://bcn.iums.ac.ir/article-1-1125-en.htmllesion studyinterval timingexplicit timingimplicit timing |
| spellingShingle | Ali Hosseini Sajjad Rezaei Alia Saberi Direct and Indirect Timing Functions in Unilateral Hemispheric Lesion Basic and Clinical Neuroscience lesion study interval timing explicit timing implicit timing |
| title | Direct and Indirect Timing Functions in Unilateral Hemispheric Lesion |
| title_full | Direct and Indirect Timing Functions in Unilateral Hemispheric Lesion |
| title_fullStr | Direct and Indirect Timing Functions in Unilateral Hemispheric Lesion |
| title_full_unstemmed | Direct and Indirect Timing Functions in Unilateral Hemispheric Lesion |
| title_short | Direct and Indirect Timing Functions in Unilateral Hemispheric Lesion |
| title_sort | direct and indirect timing functions in unilateral hemispheric lesion |
| topic | lesion study interval timing explicit timing implicit timing |
| url | http://bcn.iums.ac.ir/article-1-1125-en.html |
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