Applications of Curcumin and Its Nanoforms in the Treatment of Cancer
Due to the diverse medicinal and pharmacokinetic properties of turmeric, it is well-known in the therapeutic, pharmaceutic, nutraceutical, cosmetic, and dietary industries. It gained importance due to its multitude of properties, such as wound-healing, anti-inflammatory, anti-oxidant, anti-microbial...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/9/2223 |
| _version_ | 1827724508462579712 |
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| author | Deepa Mundekkad William C. Cho |
| author_facet | Deepa Mundekkad William C. Cho |
| author_sort | Deepa Mundekkad |
| collection | DOAJ |
| description | Due to the diverse medicinal and pharmacokinetic properties of turmeric, it is well-known in the therapeutic, pharmaceutic, nutraceutical, cosmetic, and dietary industries. It gained importance due to its multitude of properties, such as wound-healing, anti-inflammatory, anti-oxidant, anti-microbial, cytoprotective, anti-aging, anti-cancer, and immunomodulatory effects. Even though the natural healing effect of turmeric has been known to Indians as early as 2500 BCE, the global demand for turmeric has increased only recently. A major reason for the beneficiary activities of turmeric is the presence of the yellow-colored polyphenolic compound called curcumin. Many studies have been carried out on the various properties of curcumin and its derivatives. Despite its low bioavailability, curcumin has been effectively used for the treatment of many diseases, such as cardiovascular and neurological diseases, diabetes, arthritis, and cancer. The advent of nanobiotechnology has further opened wide opportunities to explore and expand the use of curcumin in the medical field. Nanoformulations using curcumin and its derivatives helped to design new treatment modalities, specifically in cancer, because of the better bioavailability and solubility of nanocurcumin when compared to natural curcumin. This review deals with the various applications of curcumin nanoparticles in cancer therapy and broadly tries to understand how it affect the immunological status of the cancer cell. |
| first_indexed | 2024-03-10T22:16:45Z |
| format | Article |
| id | doaj.art-cee0a24033644da9a61659141d9fb80b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T22:16:45Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cee0a24033644da9a61659141d9fb80b2023-11-19T12:26:42ZengMDPI AGPharmaceutics1999-49232023-08-01159222310.3390/pharmaceutics15092223Applications of Curcumin and Its Nanoforms in the Treatment of CancerDeepa Mundekkad0William C. Cho1Department of Biotechnology, Nehru Arts and Science College, Thirumalayampalayam, Coimbatore 641105, IndiaDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, ChinaDue to the diverse medicinal and pharmacokinetic properties of turmeric, it is well-known in the therapeutic, pharmaceutic, nutraceutical, cosmetic, and dietary industries. It gained importance due to its multitude of properties, such as wound-healing, anti-inflammatory, anti-oxidant, anti-microbial, cytoprotective, anti-aging, anti-cancer, and immunomodulatory effects. Even though the natural healing effect of turmeric has been known to Indians as early as 2500 BCE, the global demand for turmeric has increased only recently. A major reason for the beneficiary activities of turmeric is the presence of the yellow-colored polyphenolic compound called curcumin. Many studies have been carried out on the various properties of curcumin and its derivatives. Despite its low bioavailability, curcumin has been effectively used for the treatment of many diseases, such as cardiovascular and neurological diseases, diabetes, arthritis, and cancer. The advent of nanobiotechnology has further opened wide opportunities to explore and expand the use of curcumin in the medical field. Nanoformulations using curcumin and its derivatives helped to design new treatment modalities, specifically in cancer, because of the better bioavailability and solubility of nanocurcumin when compared to natural curcumin. This review deals with the various applications of curcumin nanoparticles in cancer therapy and broadly tries to understand how it affect the immunological status of the cancer cell.https://www.mdpi.com/1999-4923/15/9/2223curcuminnanocurcuminanti-cancerimmunomodulationsignaling pathwaysimmune tolerance |
| spellingShingle | Deepa Mundekkad William C. Cho Applications of Curcumin and Its Nanoforms in the Treatment of Cancer Pharmaceutics curcumin nanocurcumin anti-cancer immunomodulation signaling pathways immune tolerance |
| title | Applications of Curcumin and Its Nanoforms in the Treatment of Cancer |
| title_full | Applications of Curcumin and Its Nanoforms in the Treatment of Cancer |
| title_fullStr | Applications of Curcumin and Its Nanoforms in the Treatment of Cancer |
| title_full_unstemmed | Applications of Curcumin and Its Nanoforms in the Treatment of Cancer |
| title_short | Applications of Curcumin and Its Nanoforms in the Treatment of Cancer |
| title_sort | applications of curcumin and its nanoforms in the treatment of cancer |
| topic | curcumin nanocurcumin anti-cancer immunomodulation signaling pathways immune tolerance |
| url | https://www.mdpi.com/1999-4923/15/9/2223 |
| work_keys_str_mv | AT deepamundekkad applicationsofcurcuminanditsnanoformsinthetreatmentofcancer AT williamccho applicationsofcurcuminanditsnanoformsinthetreatmentofcancer |