Loss of symbiotic and increase of virulent bacteria through microbial networks in Lynch syndrome colon carcinogenesis

Loss of symbiotic and increase of virulent bacteria through microbial networks in Lynch syndrome colon carcinogenesis

PurposeThrough a pilot study, we performed whole gut metagenomic analysis in 17 Lynch syndrome (LS) families, including colorectal cancer (CRC) patients and their healthy first-degree relatives. In a second asymptomatic LS cohort (n=150) undergoing colonoscopy-screening program, individuals with ear...

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Bibliographic Details
Main Authors: Mohammad Sadeghi, Denis Mestivier, Etienne Carbonnelle, Robert Benamouzig, Khashayarsha Khazaie, Iradj Sobhani
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Oncology
Subjects:
gut microbiota
cancer
microbial network inference
Lynch syndrome
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1313735/full

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