The Roles of microRNAs in Cancer Multidrug Resistance
Cancer chemotherapy may induce a multidrug resistance (MDR) phenotype. The development of MDR is based on various molecular causes, of which the following are very common: induction of ABC transporter expression; induction/activation of drug-metabolizing enzymes; alteration of the expression/functio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/4/1090 |
| _version_ | 1797482036709031936 |
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| author | Lucia Pavlíková Mário Šereš Albert Breier Zdena Sulová |
| author_facet | Lucia Pavlíková Mário Šereš Albert Breier Zdena Sulová |
| author_sort | Lucia Pavlíková |
| collection | DOAJ |
| description | Cancer chemotherapy may induce a multidrug resistance (MDR) phenotype. The development of MDR is based on various molecular causes, of which the following are very common: induction of ABC transporter expression; induction/activation of drug-metabolizing enzymes; alteration of the expression/function of apoptosis-related proteins; changes in cell cycle checkpoints; elevated DNA repair mechanisms. Although these mechanisms of MDR are well described, information on their molecular interaction in overall multidrug resistance is still lacking. MicroRNA (miRNA) expression and subsequent RNA interference are candidates that could be important players in the interplay of MDR mechanisms. The regulation of post-transcriptional processes in the proteosynthetic pathway is considered to be a major function of miRNAs. Due to their complementarity, they are able to bind to target mRNAs, which prevents the mRNAs from interacting effectively with the ribosome, and subsequent degradation of the mRNAs can occur. The aim of this paper is to provide an overview of the possible role of miRNAs in the molecular mechanisms that lead to MDR. The possibility of considering miRNAs as either specific effectors or interesting targets for cancer therapy is also analyzed. |
| first_indexed | 2024-03-09T22:23:31Z |
| format | Article |
| id | doaj.art-cee24ddb79794d73ad805f64ab05d621 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:23:31Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cee24ddb79794d73ad805f64ab05d6212023-11-23T19:11:15ZengMDPI AGCancers2072-66942022-02-01144109010.3390/cancers14041090The Roles of microRNAs in Cancer Multidrug ResistanceLucia Pavlíková0Mário Šereš1Albert Breier2Zdena Sulová3Institute of Molecular Physiology and Genetics, Centre of Bioscience, Slovak Academy of Sciences, Dúbravská Cesta 9, 84005 Bratislava, SlovakiaInstitute of Molecular Physiology and Genetics, Centre of Bioscience, Slovak Academy of Sciences, Dúbravská Cesta 9, 84005 Bratislava, SlovakiaInstitute of Molecular Physiology and Genetics, Centre of Bioscience, Slovak Academy of Sciences, Dúbravská Cesta 9, 84005 Bratislava, SlovakiaInstitute of Molecular Physiology and Genetics, Centre of Bioscience, Slovak Academy of Sciences, Dúbravská Cesta 9, 84005 Bratislava, SlovakiaCancer chemotherapy may induce a multidrug resistance (MDR) phenotype. The development of MDR is based on various molecular causes, of which the following are very common: induction of ABC transporter expression; induction/activation of drug-metabolizing enzymes; alteration of the expression/function of apoptosis-related proteins; changes in cell cycle checkpoints; elevated DNA repair mechanisms. Although these mechanisms of MDR are well described, information on their molecular interaction in overall multidrug resistance is still lacking. MicroRNA (miRNA) expression and subsequent RNA interference are candidates that could be important players in the interplay of MDR mechanisms. The regulation of post-transcriptional processes in the proteosynthetic pathway is considered to be a major function of miRNAs. Due to their complementarity, they are able to bind to target mRNAs, which prevents the mRNAs from interacting effectively with the ribosome, and subsequent degradation of the mRNAs can occur. The aim of this paper is to provide an overview of the possible role of miRNAs in the molecular mechanisms that lead to MDR. The possibility of considering miRNAs as either specific effectors or interesting targets for cancer therapy is also analyzed.https://www.mdpi.com/2072-6694/14/4/1090miRNAmultidrug resistanceABC transporterscell cycleapoptosis |
| spellingShingle | Lucia Pavlíková Mário Šereš Albert Breier Zdena Sulová The Roles of microRNAs in Cancer Multidrug Resistance Cancers miRNA multidrug resistance ABC transporters cell cycle apoptosis |
| title | The Roles of microRNAs in Cancer Multidrug Resistance |
| title_full | The Roles of microRNAs in Cancer Multidrug Resistance |
| title_fullStr | The Roles of microRNAs in Cancer Multidrug Resistance |
| title_full_unstemmed | The Roles of microRNAs in Cancer Multidrug Resistance |
| title_short | The Roles of microRNAs in Cancer Multidrug Resistance |
| title_sort | roles of micrornas in cancer multidrug resistance |
| topic | miRNA multidrug resistance ABC transporters cell cycle apoptosis |
| url | https://www.mdpi.com/2072-6694/14/4/1090 |
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