Transcriptional Regulation of Inflammasomes
Inflammasomes are multimolecular complexes with potent inflammatory activity. As such, their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this review, we present the transcriptional regulation of inflammasome genes from sensors (e.g., NLRP3) to substrates...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/8087 |
| _version_ | 1797549406014144512 |
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| author | Maxence Cornut Emilie Bourdonnay Thomas Henry |
| author_facet | Maxence Cornut Emilie Bourdonnay Thomas Henry |
| author_sort | Maxence Cornut |
| collection | DOAJ |
| description | Inflammasomes are multimolecular complexes with potent inflammatory activity. As such, their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this review, we present the transcriptional regulation of inflammasome genes from sensors (e.g., NLRP3) to substrates (e.g., IL-1β). Lineage-determining transcription factors shape inflammasome responses in different cell types with profound consequences on the responsiveness to inflammasome-activating stimuli. Pro-inflammatory signals (sterile or microbial) have a key transcriptional impact on inflammasome genes, which is largely mediated by NF-κB and that translates into higher antimicrobial immune responses. Furthermore, diverse intrinsic (e.g., circadian clock, metabolites) or extrinsic (e.g., xenobiotics) signals are integrated by signal-dependent transcription factors and chromatin structure changes to modulate transcriptionally inflammasome responses. Finally, anti-inflammatory signals (e.g., IL-10) counterbalance inflammasome genes induction to limit deleterious inflammation. Transcriptional regulations thus appear as the first line of inflammasome regulation to raise the defense level in front of stress and infections but also to limit excessive or chronic inflammation. |
| first_indexed | 2024-03-10T15:14:15Z |
| format | Article |
| id | doaj.art-cee299212eee4f8f95fcedeffadc0e8f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:14:15Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cee299212eee4f8f95fcedeffadc0e8f2023-11-20T19:06:01ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121808710.3390/ijms21218087Transcriptional Regulation of InflammasomesMaxence Cornut0Emilie Bourdonnay1Thomas Henry2Centre International de Recherche en Infectiologie (CIRI), Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007 Lyon, FranceCentre International de Recherche en Infectiologie (CIRI), Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007 Lyon, FranceCentre International de Recherche en Infectiologie (CIRI), Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007 Lyon, FranceInflammasomes are multimolecular complexes with potent inflammatory activity. As such, their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this review, we present the transcriptional regulation of inflammasome genes from sensors (e.g., NLRP3) to substrates (e.g., IL-1β). Lineage-determining transcription factors shape inflammasome responses in different cell types with profound consequences on the responsiveness to inflammasome-activating stimuli. Pro-inflammatory signals (sterile or microbial) have a key transcriptional impact on inflammasome genes, which is largely mediated by NF-κB and that translates into higher antimicrobial immune responses. Furthermore, diverse intrinsic (e.g., circadian clock, metabolites) or extrinsic (e.g., xenobiotics) signals are integrated by signal-dependent transcription factors and chromatin structure changes to modulate transcriptionally inflammasome responses. Finally, anti-inflammatory signals (e.g., IL-10) counterbalance inflammasome genes induction to limit deleterious inflammation. Transcriptional regulations thus appear as the first line of inflammasome regulation to raise the defense level in front of stress and infections but also to limit excessive or chronic inflammation.https://www.mdpi.com/1422-0067/21/21/8087inflammasomeNF-κBIRFNLRP3caspase-1epigenetic modification |
| spellingShingle | Maxence Cornut Emilie Bourdonnay Thomas Henry Transcriptional Regulation of Inflammasomes International Journal of Molecular Sciences inflammasome NF-κB IRF NLRP3 caspase-1 epigenetic modification |
| title | Transcriptional Regulation of Inflammasomes |
| title_full | Transcriptional Regulation of Inflammasomes |
| title_fullStr | Transcriptional Regulation of Inflammasomes |
| title_full_unstemmed | Transcriptional Regulation of Inflammasomes |
| title_short | Transcriptional Regulation of Inflammasomes |
| title_sort | transcriptional regulation of inflammasomes |
| topic | inflammasome NF-κB IRF NLRP3 caspase-1 epigenetic modification |
| url | https://www.mdpi.com/1422-0067/21/21/8087 |
| work_keys_str_mv | AT maxencecornut transcriptionalregulationofinflammasomes AT emiliebourdonnay transcriptionalregulationofinflammasomes AT thomashenry transcriptionalregulationofinflammasomes |