HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan
Abstract Background Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas....
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Infectious Agents and Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s13027-018-0175-8 |
| _version_ | 1818272665801064448 |
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| author | Dauren Adilbay Galim Adilbayev Gulzhan Kidirbayeva Viktoria Shipilova Zhanat Sadyk Gulsum Koyanbekova Ekaterina Sokolenko Jan Klozar |
| author_facet | Dauren Adilbay Galim Adilbayev Gulzhan Kidirbayeva Viktoria Shipilova Zhanat Sadyk Gulsum Koyanbekova Ekaterina Sokolenko Jan Klozar |
| author_sort | Dauren Adilbay |
| collection | DOAJ |
| description | Abstract Background Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas. Th incidence of oropharyngeal cancer is increasing in many countries, and the rate of HPV positive tumors is about 70% in Europe and North America. Little known about the prevalence of HPV in HNC in Central Asia. Methods It’s a prospective analysis of patients with verified oral or oropharyngeal cancer. Sociodemographic and clinical data obtained on admission to treatment. The diagnosis of HPV positivity assessed by both the P16 expression on immunohistochemistry(IHC) and polymerase chain reaction (PCR)with HPV DNA detection and HR HPV type determination. Results Seventy six patients with oral and oropharyngeal cancer tested for HPV. Forteen cases were positive for HPV by PCR and 15 cases by P16 IHC. Of the 35 oropharyngeal tumors, nine were HPV DNA and p16 IHC positive, giving the rate of 25.7%. Of the 41 oral tumors, five were HPV DNA and six p16 IHC positive, giving the rate of 12.2%. Conclusion It is the first study mapping prevalence of HPV positivity in oral and oropharyngeal cancer in the Central Asian region. The rate of HPV positivity was higher in oropharyngeal than in oral cancer, the nonsmokers were significantly more frequent in the HPV positive group and HPV 16 was the most frequent type. However, the HPV positivity rates are lower than referred in the western world. |
| first_indexed | 2024-12-12T21:45:41Z |
| format | Article |
| id | doaj.art-cee313c620634b26a1328c91a8275755 |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-12T21:45:41Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-cee313c620634b26a1328c91a82757552022-12-22T00:10:56ZengBMCInfectious Agents and Cancer1750-93782018-01-011311410.1186/s13027-018-0175-8HPV infection and P16 expression in oral and oropharyngeal cancer in KazakhstanDauren Adilbay0Galim Adilbayev1Gulzhan Kidirbayeva2Viktoria Shipilova3Zhanat Sadyk4Gulsum Koyanbekova5Ekaterina Sokolenko6Jan Klozar7Kazakh Institute of Oncology and RadiologyHead and neck oncology center, Kazakh Institute of Oncology and RadiologyHead and neck oncology center, Kazakh Institute of Oncology and RadiologyHead and neck oncology center, Kazakh Institute of Oncology and RadiologyHead and neck oncology center, Kazakh Institute of Oncology and RadiologyPathology and molecular biology department, Kazakh Institute of Oncology and RadiologyPathology and molecular biology department, Kazakh Institute of Oncology and RadiologyCharles University in Prague, University Hospital MotolAbstract Background Human papillomavirus (HPV) is an important etiologic factor in different cancers of anogenital region and also in a fraction of head and neck cancers (HNC) particularly oropharyngeal tumors. The HPV16 genotype associated with the majority of HPV-related head and neck carcinomas. Th incidence of oropharyngeal cancer is increasing in many countries, and the rate of HPV positive tumors is about 70% in Europe and North America. Little known about the prevalence of HPV in HNC in Central Asia. Methods It’s a prospective analysis of patients with verified oral or oropharyngeal cancer. Sociodemographic and clinical data obtained on admission to treatment. The diagnosis of HPV positivity assessed by both the P16 expression on immunohistochemistry(IHC) and polymerase chain reaction (PCR)with HPV DNA detection and HR HPV type determination. Results Seventy six patients with oral and oropharyngeal cancer tested for HPV. Forteen cases were positive for HPV by PCR and 15 cases by P16 IHC. Of the 35 oropharyngeal tumors, nine were HPV DNA and p16 IHC positive, giving the rate of 25.7%. Of the 41 oral tumors, five were HPV DNA and six p16 IHC positive, giving the rate of 12.2%. Conclusion It is the first study mapping prevalence of HPV positivity in oral and oropharyngeal cancer in the Central Asian region. The rate of HPV positivity was higher in oropharyngeal than in oral cancer, the nonsmokers were significantly more frequent in the HPV positive group and HPV 16 was the most frequent type. However, the HPV positivity rates are lower than referred in the western world.http://link.springer.com/article/10.1186/s13027-018-0175-8HPVOral cavityOropharyngeal cancerp16 IHCKazakhstanThis research was presented as an E-poster on IFOS 2017 ENT world congress (24–28 June) Paris, France. Abstract № HN-HPV-20. |
| spellingShingle | Dauren Adilbay Galim Adilbayev Gulzhan Kidirbayeva Viktoria Shipilova Zhanat Sadyk Gulsum Koyanbekova Ekaterina Sokolenko Jan Klozar HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan Infectious Agents and Cancer HPV Oral cavity Oropharyngeal cancer p16 IHC Kazakhstan This research was presented as an E-poster on IFOS 2017 ENT world congress (24–28 June) Paris, France. Abstract № HN-HPV-20. |
| title | HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan |
| title_full | HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan |
| title_fullStr | HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan |
| title_full_unstemmed | HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan |
| title_short | HPV infection and P16 expression in oral and oropharyngeal cancer in Kazakhstan |
| title_sort | hpv infection and p16 expression in oral and oropharyngeal cancer in kazakhstan |
| topic | HPV Oral cavity Oropharyngeal cancer p16 IHC Kazakhstan This research was presented as an E-poster on IFOS 2017 ENT world congress (24–28 June) Paris, France. Abstract № HN-HPV-20. |
| url | http://link.springer.com/article/10.1186/s13027-018-0175-8 |
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