Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil
Objectives: Mentha longifolia L. (Lamiaceae) is an annual herb that is used in the Iranian traditional medicine for treating stomach and intestinal disorders. The purpose of this study was to determine the protective effect of M. longifolia on experimental diarrhea in a rat model. Materials and Meth...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2015-02-01
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| Series: | Avicenna Journal of Phytomedicine |
| Subjects: | |
| Online Access: | http://ajp.mums.ac.ir/pdf_3937_5af51255ef6057cd4d8e901ae677b3b9.html |
| _version_ | 1819092072032894976 |
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| author | Ghader Jalilzadeh-Amin Massoud Maham |
| author_facet | Ghader Jalilzadeh-Amin Massoud Maham |
| author_sort | Ghader Jalilzadeh-Amin |
| collection | DOAJ |
| description | Objectives: Mentha longifolia L. (Lamiaceae) is an annual herb that is used in the Iranian traditional medicine for treating stomach and intestinal disorders. The purpose of this study was to determine the protective effect of M. longifolia on experimental diarrhea in a rat model. Materials and Methods: The antidiarrheal activity of essential oil of M. longifolia (20-80 mg/kg) was investigated against castor oil-induced diarrhea in rats using loperamide as the standard reference drug. In acute toxicity evaluation, rats were orally administrated with single dose of EOML at doses ranging from 10 to 1000 mg/kg. Results: EOML caused a significant (p |
| first_indexed | 2024-12-21T22:49:48Z |
| format | Article |
| id | doaj.art-cee407f0743e4a9b9d4ef52a61d7ecc7 |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-12-21T22:49:48Z |
| publishDate | 2015-02-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-cee407f0743e4a9b9d4ef52a61d7ecc72022-12-21T18:47:37ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492015-02-01521281373937Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oilGhader Jalilzadeh-Amin0Massoud Maham1Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranObjectives: Mentha longifolia L. (Lamiaceae) is an annual herb that is used in the Iranian traditional medicine for treating stomach and intestinal disorders. The purpose of this study was to determine the protective effect of M. longifolia on experimental diarrhea in a rat model. Materials and Methods: The antidiarrheal activity of essential oil of M. longifolia (20-80 mg/kg) was investigated against castor oil-induced diarrhea in rats using loperamide as the standard reference drug. In acute toxicity evaluation, rats were orally administrated with single dose of EOML at doses ranging from 10 to 1000 mg/kg. Results: EOML caused a significant (phttp://ajp.mums.ac.ir/pdf_3937_5af51255ef6057cd4d8e901ae677b3b9.htmlIntestinal transitDiarrheaAntispasmodicEssential oilCastor oilLD50 |
| spellingShingle | Ghader Jalilzadeh-Amin Massoud Maham Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil Avicenna Journal of Phytomedicine Intestinal transit Diarrhea Antispasmodic Essential oil Castor oil LD50 |
| title | Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil |
| title_full | Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil |
| title_fullStr | Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil |
| title_full_unstemmed | Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil |
| title_short | Antidiarrheal activity and acute oral toxicity of Mentha longifolia L. essential oil |
| title_sort | antidiarrheal activity and acute oral toxicity of mentha longifolia l essential oil |
| topic | Intestinal transit Diarrhea Antispasmodic Essential oil Castor oil LD50 |
| url | http://ajp.mums.ac.ir/pdf_3937_5af51255ef6057cd4d8e901ae677b3b9.html |
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