Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy Populations
Fluoroquinolone (FQ) antibiotics have been shown to reduce mortality and the number of febrile episodes when used as prophylaxis during neutropenia. Prior studies suggest that prophylaxis may result in increasing rates of FQ resistance. Fluoroquinolone non-susceptibility trends in Escherichia coli i...
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| Format: | Article |
| Language: | English |
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Case Western Reserve University
2016-09-01
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| Series: | Pathogens and Immunity |
| Subjects: | |
| Online Access: | https://paijournal.com/index.php/paijournal/article/view/115 |
| _version_ | 1811326789115445248 |
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| author | Christopher G. Hauck Pearlie P. Chong Melissa B. Miller Katarzyna Jamieson Jason P. Fine Matthew C. Foster Thomas C. Shea David van Duin |
| author_facet | Christopher G. Hauck Pearlie P. Chong Melissa B. Miller Katarzyna Jamieson Jason P. Fine Matthew C. Foster Thomas C. Shea David van Duin |
| author_sort | Christopher G. Hauck |
| collection | DOAJ |
| description | Fluoroquinolone (FQ) antibiotics have been shown to reduce mortality and the number of febrile episodes when used as prophylaxis during neutropenia. Prior studies suggest that prophylaxis may result in increasing rates of FQ resistance. Fluoroquinolone non-susceptibility trends in Escherichia coli isolated from blood and urine cultures were evaluated over a 16-year period during which prophylaxis was initiated in patients with hematologic malignancies and stem cell transplants. Non-susceptibility rates increased after the introduction of prophylaxis, with yearly non-susceptibility rates rising from 30%–33% to 40%–88% in blood isolates. The high rates of non-susceptibility now observed raise concerns about the continued efficacy of FQ prophylaxis. This concern exists particularly in those patients undergoing stem cell transplants where the total FQ non-susceptibility rates over the study period were 82.3%. Further evaluation of the effect of FQ prophylaxis on antibiotic resistance and its efficacy in the setting of increased rates of resistance is warranted. |
| first_indexed | 2024-04-13T14:55:36Z |
| format | Article |
| id | doaj.art-cee5a856a4c34b67b6cff333ac68de55 |
| institution | Directory Open Access Journal |
| issn | 2469-2964 |
| language | English |
| last_indexed | 2024-04-13T14:55:36Z |
| publishDate | 2016-09-01 |
| publisher | Case Western Reserve University |
| record_format | Article |
| series | Pathogens and Immunity |
| spelling | doaj.art-cee5a856a4c34b67b6cff333ac68de552022-12-22T02:42:27ZengCase Western Reserve UniversityPathogens and Immunity2469-29642016-09-011223424210.20411/pai.v1i2.11527Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy PopulationsChristopher G. Hauck0Pearlie P. Chong1Melissa B. Miller2Katarzyna Jamieson3Jason P. Fine4Matthew C. Foster5Thomas C. Shea6David van Duin7Division of Infectious Diseases, University of North Carolina, Chapel Hill, NCDivision of Infectious Diseases, University of North Carolina, Chapel Hill, NCDepartment of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NCDivision of Hematology/Oncology, University of North Carolina, Chapel Hill, NCBiostatistics Department, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NCDivision of Hematology/Oncology, University of North Carolina, Chapel Hill, NCDivision of Hematology/Oncology, University of North Carolina, Chapel Hill, NCDivision of Infectious Diseases, University of North Carolina, Chapel Hill, NCFluoroquinolone (FQ) antibiotics have been shown to reduce mortality and the number of febrile episodes when used as prophylaxis during neutropenia. Prior studies suggest that prophylaxis may result in increasing rates of FQ resistance. Fluoroquinolone non-susceptibility trends in Escherichia coli isolated from blood and urine cultures were evaluated over a 16-year period during which prophylaxis was initiated in patients with hematologic malignancies and stem cell transplants. Non-susceptibility rates increased after the introduction of prophylaxis, with yearly non-susceptibility rates rising from 30%–33% to 40%–88% in blood isolates. The high rates of non-susceptibility now observed raise concerns about the continued efficacy of FQ prophylaxis. This concern exists particularly in those patients undergoing stem cell transplants where the total FQ non-susceptibility rates over the study period were 82.3%. Further evaluation of the effect of FQ prophylaxis on antibiotic resistance and its efficacy in the setting of increased rates of resistance is warranted.https://paijournal.com/index.php/paijournal/article/view/115Fluoroquinolone resistanceEscherichia colistem cell transplanthematologic malignancy |
| spellingShingle | Christopher G. Hauck Pearlie P. Chong Melissa B. Miller Katarzyna Jamieson Jason P. Fine Matthew C. Foster Thomas C. Shea David van Duin Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy Populations Pathogens and Immunity Fluoroquinolone resistance Escherichia coli stem cell transplant hematologic malignancy |
| title | Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy Populations |
| title_full | Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy Populations |
| title_fullStr | Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy Populations |
| title_full_unstemmed | Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy Populations |
| title_short | Increasing Rates of Fluoroquinolone Resistance in Escherichia coli Blood and Urinary Isolates in Stem Cell Transplant and Hematologic Malignancy Populations |
| title_sort | increasing rates of fluoroquinolone resistance in escherichia coli blood and urinary isolates in stem cell transplant and hematologic malignancy populations |
| topic | Fluoroquinolone resistance Escherichia coli stem cell transplant hematologic malignancy |
| url | https://paijournal.com/index.php/paijournal/article/view/115 |
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