Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers
Currently, cancer chemotherapeutic drugs still have the defects of high toxicity and low bioavailability, so it is critical to design novel drug release systems for cancer chemotherapy. Here, we report a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for anti...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Journal of Functional Biomaterials |
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| Online Access: | https://www.mdpi.com/2079-4983/13/2/55 |
| _version_ | 1797485854088757248 |
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| author | Zhe Wang Yili Zhao Mingwu Shen Helena Tomás Benqing Zhou Xiangyang Shi |
| author_facet | Zhe Wang Yili Zhao Mingwu Shen Helena Tomás Benqing Zhou Xiangyang Shi |
| author_sort | Zhe Wang |
| collection | DOAJ |
| description | Currently, cancer chemotherapeutic drugs still have the defects of high toxicity and low bioavailability, so it is critical to design novel drug release systems for cancer chemotherapy. Here, we report a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antitumor therapy applications. In this work, rod-like attapulgite (ATT) was utilized to load a model anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT/DOX/PLGA composite nanofibers were characterized through various techniques. It is feasible to load DOX onto ATT surfaces, and the ATT/DOX/PLGA nanofibers show a smooth and uniform morphology with improved mechanical durability. Under neutral and acidic pH conditions, the loaded DOX was released from ATT/DOX/PLGA nanofibers in a sustained manner. In addition, the released DOX from the nanofibers could significantly inhibit the growth of tumor cells. Owing to the significantly reduced burst release profile and increased mechanical durability of the ATT/DOX/PLGA nanofibers, the designed organic–inorganic hybrid nanofibers may hold great promise as a nanoplatform to encapsulate different drugs for enhanced local tumor therapy applications. |
| first_indexed | 2024-03-09T23:25:44Z |
| format | Article |
| id | doaj.art-cee5f6f870174d1597d9942f9a22ebfb |
| institution | Directory Open Access Journal |
| issn | 2079-4983 |
| language | English |
| last_indexed | 2024-03-09T23:25:44Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Functional Biomaterials |
| spelling | doaj.art-cee5f6f870174d1597d9942f9a22ebfb2023-11-23T17:19:26ZengMDPI AGJournal of Functional Biomaterials2079-49832022-05-011325510.3390/jfb13020055Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite NanofibersZhe Wang0Yili Zhao1Mingwu Shen2Helena Tomás3Benqing Zhou4Xiangyang Shi5Department of Biomedical Engineering, College of Engineering, Shantou University, Shantou 515063, ChinaCollege of Textile Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, ChinaShanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, ChinaCQM—Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, PortugalDepartment of Biomedical Engineering, College of Engineering, Shantou University, Shantou 515063, ChinaShanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, ChinaCurrently, cancer chemotherapeutic drugs still have the defects of high toxicity and low bioavailability, so it is critical to design novel drug release systems for cancer chemotherapy. Here, we report a method to fabricate electrospun drug-loaded organic/inorganic hybrid nanofibrous system for antitumor therapy applications. In this work, rod-like attapulgite (ATT) was utilized to load a model anticancer drug doxorubicin (DOX), and mixed with poly(lactic-co-glycolic acid) (PLGA) to form electrospun hybrid nanofibers. The ATT/DOX/PLGA composite nanofibers were characterized through various techniques. It is feasible to load DOX onto ATT surfaces, and the ATT/DOX/PLGA nanofibers show a smooth and uniform morphology with improved mechanical durability. Under neutral and acidic pH conditions, the loaded DOX was released from ATT/DOX/PLGA nanofibers in a sustained manner. In addition, the released DOX from the nanofibers could significantly inhibit the growth of tumor cells. Owing to the significantly reduced burst release profile and increased mechanical durability of the ATT/DOX/PLGA nanofibers, the designed organic–inorganic hybrid nanofibers may hold great promise as a nanoplatform to encapsulate different drugs for enhanced local tumor therapy applications.https://www.mdpi.com/2079-4983/13/2/55nanofibersattapulgitedrug releasepoly(lactic-co-glycolic acid)antitumor therapy |
| spellingShingle | Zhe Wang Yili Zhao Mingwu Shen Helena Tomás Benqing Zhou Xiangyang Shi Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers Journal of Functional Biomaterials nanofibers attapulgite drug release poly(lactic-co-glycolic acid) antitumor therapy |
| title | Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers |
| title_full | Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers |
| title_fullStr | Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers |
| title_full_unstemmed | Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers |
| title_short | Antitumor Efficacy of Doxorubicin-Loaded Electrospun Attapulgite–Poly(lactic-co-glycolic acid) Composite Nanofibers |
| title_sort | antitumor efficacy of doxorubicin loaded electrospun attapulgite poly lactic co glycolic acid composite nanofibers |
| topic | nanofibers attapulgite drug release poly(lactic-co-glycolic acid) antitumor therapy |
| url | https://www.mdpi.com/2079-4983/13/2/55 |
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