Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery
Yinshan Lin,1,2,* Xiaoling Guan,1,2,* Jianfen Su,1,2,* Sheng Chen,2 Xihua Fu,1 Xiaowei Xu,2 Xiaohua Deng,2 Jishuo Chang,2 Aiping Qin,2,* Ao Shen,2,* Lingmin Zhang1,2,* 1Pharmacy Department & Panyu Institute of Infectious Diseases, Guangzhou Panyu C...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-12-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/cell-membrane-camouflaged-nanoparticles-mediated-nucleic-acids-deliver-peer-reviewed-fulltext-article-IJN |
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| author | Lin Y Guan X Su J Chen S Fu X Xu X Deng X Chang J Qin A Shen A Zhang L |
| author_facet | Lin Y Guan X Su J Chen S Fu X Xu X Deng X Chang J Qin A Shen A Zhang L |
| author_sort | Lin Y |
| collection | DOAJ |
| description | Yinshan Lin,1,2,* Xiaoling Guan,1,2,* Jianfen Su,1,2,* Sheng Chen,2 Xihua Fu,1 Xiaowei Xu,2 Xiaohua Deng,2 Jishuo Chang,2 Aiping Qin,2,* Ao Shen,2,* Lingmin Zhang1,2,* 1Pharmacy Department & Panyu Institute of Infectious Diseases, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, 511400, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingmin Zhang, Guangzhou Panyu Central Hospital, No. 8 Fuyu East Road, Guangzhou, Guangdong, 511400, People’s Republic of China, Email zhanglm@gzhmu.edu.cn Ao Shen; Aiping Qin, Guangzhou Medical University, No. 1 Xinzao Road, Guangzhou, Guangdong, 511426, People’s Republic of China, Email shenao@gzhmu.edu.cn; qinaiping_2008@163.comAbstract: Nucleic acids have emerged as promising therapeutic agents for many diseases because of their potential in modulating gene expression. However, the delivery of nucleic acids remains a significant challenge in gene therapy. Although viral vectors have shown high transfection efficiency, concerns regarding teratogenicity or carcinogenicity have been raised. Non-viral vehicles, including cationic polymers, liposomes, and inorganic materials possess advantages in terms of safety, ease of preparation, and low cost. Nevertheless, they also face limitations related to immunogenicity, quick clearance in vivo, and lack of targeting specificity. On the other hand, bioinspired strategies have shown increasing potential in the field of drug delivery, yet there is a lack of comprehensive reviews summarizing the rapid development of bioinspired nanoparticles based on the cell membrane camouflage to construct the nucleic acids vehicles. Herein, we enumerated the current difficulties in nucleic acid delivery with various non-viral vehicles and provided an overview of bioinspired strategies for nucleic acid delivery. Keywords: nucleic acids, bioinspired nanoparticles, non-viral vehicles, gene therapy, cell membranes |
| first_indexed | 2024-03-08T18:51:24Z |
| format | Article |
| id | doaj.art-cee6ae11e6c8470cb3812c0679f633e3 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-08T18:51:24Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-cee6ae11e6c8470cb3812c0679f633e32023-12-28T18:07:22ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-12-01Volume 188001802189354Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids DeliveryLin YGuan XSu JChen SFu XXu XDeng XChang JQin AShen AZhang LYinshan Lin,1,2,* Xiaoling Guan,1,2,* Jianfen Su,1,2,* Sheng Chen,2 Xihua Fu,1 Xiaowei Xu,2 Xiaohua Deng,2 Jishuo Chang,2 Aiping Qin,2,* Ao Shen,2,* Lingmin Zhang1,2,* 1Pharmacy Department & Panyu Institute of Infectious Diseases, Guangzhou Panyu Central Hospital, Guangzhou, Guangdong, 511400, People’s Republic of China; 2Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lingmin Zhang, Guangzhou Panyu Central Hospital, No. 8 Fuyu East Road, Guangzhou, Guangdong, 511400, People’s Republic of China, Email zhanglm@gzhmu.edu.cn Ao Shen; Aiping Qin, Guangzhou Medical University, No. 1 Xinzao Road, Guangzhou, Guangdong, 511426, People’s Republic of China, Email shenao@gzhmu.edu.cn; qinaiping_2008@163.comAbstract: Nucleic acids have emerged as promising therapeutic agents for many diseases because of their potential in modulating gene expression. However, the delivery of nucleic acids remains a significant challenge in gene therapy. Although viral vectors have shown high transfection efficiency, concerns regarding teratogenicity or carcinogenicity have been raised. Non-viral vehicles, including cationic polymers, liposomes, and inorganic materials possess advantages in terms of safety, ease of preparation, and low cost. Nevertheless, they also face limitations related to immunogenicity, quick clearance in vivo, and lack of targeting specificity. On the other hand, bioinspired strategies have shown increasing potential in the field of drug delivery, yet there is a lack of comprehensive reviews summarizing the rapid development of bioinspired nanoparticles based on the cell membrane camouflage to construct the nucleic acids vehicles. Herein, we enumerated the current difficulties in nucleic acid delivery with various non-viral vehicles and provided an overview of bioinspired strategies for nucleic acid delivery. Keywords: nucleic acids, bioinspired nanoparticles, non-viral vehicles, gene therapy, cell membraneshttps://www.dovepress.com/cell-membrane-camouflaged-nanoparticles-mediated-nucleic-acids-deliver-peer-reviewed-fulltext-article-IJNnucleic acidsbioinspired nanoparticlesnon-viral vehiclesgene therapycell membranes |
| spellingShingle | Lin Y Guan X Su J Chen S Fu X Xu X Deng X Chang J Qin A Shen A Zhang L Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery International Journal of Nanomedicine nucleic acids bioinspired nanoparticles non-viral vehicles gene therapy cell membranes |
| title | Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery |
| title_full | Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery |
| title_fullStr | Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery |
| title_full_unstemmed | Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery |
| title_short | Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery |
| title_sort | cell membrane camouflaged nanoparticles mediated nucleic acids delivery |
| topic | nucleic acids bioinspired nanoparticles non-viral vehicles gene therapy cell membranes |
| url | https://www.dovepress.com/cell-membrane-camouflaged-nanoparticles-mediated-nucleic-acids-deliver-peer-reviewed-fulltext-article-IJN |
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