Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations
Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report preliminary in vivo studies of GBM treatments based on photo-nanotherapeutics to activate synergistic killing mechanisms. Core-shell nanoparticle...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-01-01
|
| Series: | Journal of Nanotheranostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2624-845X/3/1/1 |
| _version_ | 1818332342964453376 |
|---|---|
| author | Loredana Ricciardi Sharmistha Chatterjee Giovanna Palermo Elisabeta I. Szerb Alessia Sanna Francesca Palermo Nicola Pieroni Michela Fratini Roberto Bartolino Alessia Cedola Massimo La Deda Giuseppe Strangi |
| author_facet | Loredana Ricciardi Sharmistha Chatterjee Giovanna Palermo Elisabeta I. Szerb Alessia Sanna Francesca Palermo Nicola Pieroni Michela Fratini Roberto Bartolino Alessia Cedola Massimo La Deda Giuseppe Strangi |
| author_sort | Loredana Ricciardi |
| collection | DOAJ |
| description | Glioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report preliminary in vivo studies of GBM treatments based on photo-nanotherapeutics to activate synergistic killing mechanisms. Core-shell nanoparticles have been weaponized by combining photophysical properties of a new generation PDT agent (Ir(III) complex) with the thermoplasmonic effects of resonant gold nanospheres. In order to investigate the damages induced in GBM treated with these photoactivable nanosystems, we employed X-ray phase-contrast tomography (XPCT). This high-resolution three-dimensional imaging technique highlighted a vast devascularization process by micro-vessels disruption, which is indicative of tumor elimination without relapse. |
| first_indexed | 2024-12-13T13:34:14Z |
| format | Article |
| id | doaj.art-cee71d489abc4a83b00588eae827980a |
| institution | Directory Open Access Journal |
| issn | 2624-845X |
| language | English |
| last_indexed | 2024-12-13T13:34:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Nanotheranostics |
| spelling | doaj.art-cee71d489abc4a83b00588eae827980a2022-12-21T23:44:00ZengMDPI AGJournal of Nanotheranostics2624-845X2022-01-013111710.3390/jnt3010001Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography InvestigationsLoredana Ricciardi0Sharmistha Chatterjee1Giovanna Palermo2Elisabeta I. Szerb3Alessia Sanna4Francesca Palermo5Nicola Pieroni6Michela Fratini7Roberto Bartolino8Alessia Cedola9Massimo La Deda10Giuseppe Strangi11CNR NANOTEC-Institute of Nanotechnology U.O.S. Cosenza, 87036 Rende, ItalyDepartment of Physics, University of Calabria, 87036 Rende, ItalyCNR NANOTEC-Institute of Nanotechnology U.O.S. Cosenza, 87036 Rende, ItalyCoriolan Dragulescu Institute of Chemistry, Romanian Academy, 24 Mihai Viteazu Bvd., 300223 Timisoara, RomaniaCNR NANOTEC-Institute of Nanotechnology U.O.S. Roma, Piazzale Aldo Moro 5, 00185 Roma, ItalyDepartment of Physics, University of Calabria, 87036 Rende, ItalyCNR NANOTEC-Institute of Nanotechnology U.O.S. Roma, Piazzale Aldo Moro 5, 00185 Roma, ItalyCNR NANOTEC-Institute of Nanotechnology U.O.S. Roma, Piazzale Aldo Moro 5, 00185 Roma, ItalyCNR NANOTEC-Institute of Nanotechnology U.O.S. Cosenza, 87036 Rende, ItalyCNR NANOTEC-Institute of Nanotechnology U.O.S. Roma, Piazzale Aldo Moro 5, 00185 Roma, ItalyCNR NANOTEC-Institute of Nanotechnology U.O.S. Cosenza, 87036 Rende, ItalyCNR NANOTEC-Institute of Nanotechnology U.O.S. Cosenza, 87036 Rende, ItalyGlioblastoma multiforme (GBM) is one of the deadliest and most aggressive cancers, remarkably resilient to current therapeutic treatments. Here, we report preliminary in vivo studies of GBM treatments based on photo-nanotherapeutics to activate synergistic killing mechanisms. Core-shell nanoparticles have been weaponized by combining photophysical properties of a new generation PDT agent (Ir(III) complex) with the thermoplasmonic effects of resonant gold nanospheres. In order to investigate the damages induced in GBM treated with these photoactivable nanosystems, we employed X-ray phase-contrast tomography (XPCT). This high-resolution three-dimensional imaging technique highlighted a vast devascularization process by micro-vessels disruption, which is indicative of tumor elimination without relapse.https://www.mdpi.com/2624-845X/3/1/1gold–silica nanoparticlesphototherapyglioblastoma multiformeX-ray phase-contrast tomography |
| spellingShingle | Loredana Ricciardi Sharmistha Chatterjee Giovanna Palermo Elisabeta I. Szerb Alessia Sanna Francesca Palermo Nicola Pieroni Michela Fratini Roberto Bartolino Alessia Cedola Massimo La Deda Giuseppe Strangi Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations Journal of Nanotheranostics gold–silica nanoparticles phototherapy glioblastoma multiforme X-ray phase-contrast tomography |
| title | Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations |
| title_full | Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations |
| title_fullStr | Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations |
| title_full_unstemmed | Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations |
| title_short | Hybrid Nanoparticles as Theranostics Platforms for Glioblastoma Treatment: Phototherapeutic and X-ray Phase Contrast Tomography Investigations |
| title_sort | hybrid nanoparticles as theranostics platforms for glioblastoma treatment phototherapeutic and x ray phase contrast tomography investigations |
| topic | gold–silica nanoparticles phototherapy glioblastoma multiforme X-ray phase-contrast tomography |
| url | https://www.mdpi.com/2624-845X/3/1/1 |
| work_keys_str_mv | AT loredanaricciardi hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT sharmisthachatterjee hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT giovannapalermo hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT elisabetaiszerb hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT alessiasanna hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT francescapalermo hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT nicolapieroni hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT michelafratini hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT robertobartolino hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT alessiacedola hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT massimoladeda hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations AT giuseppestrangi hybridnanoparticlesastheranosticsplatformsforglioblastomatreatmentphototherapeuticandxrayphasecontrasttomographyinvestigations |