Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework
Tetrahedral DNA framework-enabled bulk enzyme heterojunctions have been used to program biosensor interfaces. Here, the authors use DNA tetrahedrons to tether enzymes of an enzymatic cascade to gold electrodes, hence raising them over the bulk solution, which led to improved kinetics and sensitivity...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-14664-8 |
| _version_ | 1818839372070387712 |
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| author | Ping Song Juwen Shen Dekai Ye Baijun Dong Fei Wang Hao Pei Jianbang Wang Jiye Shi Lihua Wang Wei Xue Yiran Huang Gang Huang Xiaolei Zuo Chunhai Fan |
| author_facet | Ping Song Juwen Shen Dekai Ye Baijun Dong Fei Wang Hao Pei Jianbang Wang Jiye Shi Lihua Wang Wei Xue Yiran Huang Gang Huang Xiaolei Zuo Chunhai Fan |
| author_sort | Ping Song |
| collection | DOAJ |
| description | Tetrahedral DNA framework-enabled bulk enzyme heterojunctions have been used to program biosensor interfaces. Here, the authors use DNA tetrahedrons to tether enzymes of an enzymatic cascade to gold electrodes, hence raising them over the bulk solution, which led to improved kinetics and sensitivity. |
| first_indexed | 2024-12-19T03:53:14Z |
| format | Article |
| id | doaj.art-cee74c29aa11488d98d7855042329004 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:53:14Z |
| publishDate | 2020-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-cee74c29aa11488d98d78550423290042022-12-21T20:36:55ZengNature PortfolioNature Communications2041-17232020-02-0111111010.1038/s41467-020-14664-8Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA frameworkPing Song0Juwen Shen1Dekai Ye2Baijun Dong3Fei Wang4Hao Pei5Jianbang Wang6Jiye Shi7Lihua Wang8Wei Xue9Yiran Huang10Gang Huang11Xiaolei Zuo12Chunhai Fan13Institute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal UniversityDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of SciencesInstitute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal UniversityFrontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong UniversityDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of SciencesDivision of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Institute of Applied Physics, Chinese Academy of SciencesInstitute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityInstitute of Molecular Medicine, Department of Urology, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityTetrahedral DNA framework-enabled bulk enzyme heterojunctions have been used to program biosensor interfaces. Here, the authors use DNA tetrahedrons to tether enzymes of an enzymatic cascade to gold electrodes, hence raising them over the bulk solution, which led to improved kinetics and sensitivity.https://doi.org/10.1038/s41467-020-14664-8 |
| spellingShingle | Ping Song Juwen Shen Dekai Ye Baijun Dong Fei Wang Hao Pei Jianbang Wang Jiye Shi Lihua Wang Wei Xue Yiran Huang Gang Huang Xiaolei Zuo Chunhai Fan Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework Nature Communications |
| title | Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework |
| title_full | Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework |
| title_fullStr | Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework |
| title_full_unstemmed | Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework |
| title_short | Programming bulk enzyme heterojunctions for biosensor development with tetrahedral DNA framework |
| title_sort | programming bulk enzyme heterojunctions for biosensor development with tetrahedral dna framework |
| url | https://doi.org/10.1038/s41467-020-14664-8 |
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