Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice

Disulfiram Protects Against Radiation-Induced Intestinal Injury in Mice

Radiation-induced intestinal injury (RIII) occurs after high doses of radiation exposure. RIII restricts the therapeutic efficacy of radiotherapy in cancer and increases morbidity and mortality in nuclear disasters. Currently, there is no approved agent for the prevention or treatment of RIII. Here,...

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Bibliographic Details
Main Authors: Qingwen Yuan, Renjun Peng, Huijie Yu, Sinian Wang, Zhongmin Chen, Suhe Dong, Wei Li, Bo Cheng, Qisheng Jiang, Yuwen Cong, Fengsheng Li, Changzheng Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
disulfiram
radioprotector
radiation-induced intestinal injury
Lgr5+ stem cell
DNA damage
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.852669/full

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