The Skin Epilipidome in Stress, Aging, and Inflammation
Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface lipids, together regulating permeability, physic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2020.607076/full |
| _version_ | 1818732384774782976 |
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| author | Florian Gruber Florian Gruber Florian Gruber Martina Marchetti-Deschmann Martina Marchetti-Deschmann Christopher Kremslehner Christopher Kremslehner Christopher Kremslehner Markus Schosserer Markus Schosserer Markus Schosserer |
| author_facet | Florian Gruber Florian Gruber Florian Gruber Martina Marchetti-Deschmann Martina Marchetti-Deschmann Christopher Kremslehner Christopher Kremslehner Christopher Kremslehner Markus Schosserer Markus Schosserer Markus Schosserer |
| author_sort | Florian Gruber |
| collection | DOAJ |
| description | Lipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface lipids, together regulating permeability, physical properties, acidification and the antimicrobial defense. Recent advances in accuracy and specificity of mass spectrometry have allowed studying enzymatic and non-enzymatic modifications of lipids—the epilipidome—multiplying the known diversity of molecules in this class. As the skin is an organ that is frequently exposed to oxidative-, chemical- and thermal stress, and to injury and inflammation, it is an ideal organ to study epilipidome dynamics, their causes, and their biological consequences. Recent studies uncover loss or gain in biological function resulting from either specific modifications or the sum of the modifications of lipids. These studies suggest an important role for the epilipidome in stress responses and immune regulation in the skin. In this minireview we provide a short survey of the recent developments on causes and consequences of epilipidomic changes in the skin or in cell types that reside in the skin. |
| first_indexed | 2024-12-17T23:32:43Z |
| format | Article |
| id | doaj.art-cee8d6107488478e8e379d45984f8586 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-17T23:32:43Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-cee8d6107488478e8e379d45984f85862022-12-21T21:28:38ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-01-011110.3389/fendo.2020.607076607076The Skin Epilipidome in Stress, Aging, and InflammationFlorian Gruber0Florian Gruber1Florian Gruber2Martina Marchetti-Deschmann3Martina Marchetti-Deschmann4Christopher Kremslehner5Christopher Kremslehner6Christopher Kremslehner7Markus Schosserer8Markus Schosserer9Markus Schosserer10Christian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE -, Vienna, AustriaChristian Doppler Laboratory on Biotechnology of Skin Aging, Vienna, AustriaDepartment of Dermatology, Medical University of Vienna, Vienna, AustriaChristian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE -, Vienna, AustriaInstitute of Chemical Technologies and Analytics, TU Wien, Vienna, AustriaChristian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE -, Vienna, AustriaChristian Doppler Laboratory on Biotechnology of Skin Aging, Vienna, AustriaDepartment of Dermatology, Medical University of Vienna, Vienna, AustriaChristian Doppler Laboratory for Skin Multimodal Imaging of Aging and Senescence - SKINMAGINE -, Vienna, AustriaChristian Doppler Laboratory on Biotechnology of Skin Aging, Vienna, AustriaInstitute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, AustriaLipids are highly diverse biomolecules crucial for the formation and function of cellular membranes, for metabolism, and for cellular signaling. In the mammalian skin, lipids additionally serve for the formation of the epidermal barrier and as surface lipids, together regulating permeability, physical properties, acidification and the antimicrobial defense. Recent advances in accuracy and specificity of mass spectrometry have allowed studying enzymatic and non-enzymatic modifications of lipids—the epilipidome—multiplying the known diversity of molecules in this class. As the skin is an organ that is frequently exposed to oxidative-, chemical- and thermal stress, and to injury and inflammation, it is an ideal organ to study epilipidome dynamics, their causes, and their biological consequences. Recent studies uncover loss or gain in biological function resulting from either specific modifications or the sum of the modifications of lipids. These studies suggest an important role for the epilipidome in stress responses and immune regulation in the skin. In this minireview we provide a short survey of the recent developments on causes and consequences of epilipidomic changes in the skin or in cell types that reside in the skin.https://www.frontiersin.org/articles/10.3389/fendo.2020.607076/fullskinultravioletinflammationstressoxidized phospholipidepilipidome |
| spellingShingle | Florian Gruber Florian Gruber Florian Gruber Martina Marchetti-Deschmann Martina Marchetti-Deschmann Christopher Kremslehner Christopher Kremslehner Christopher Kremslehner Markus Schosserer Markus Schosserer Markus Schosserer The Skin Epilipidome in Stress, Aging, and Inflammation Frontiers in Endocrinology skin ultraviolet inflammation stress oxidized phospholipid epilipidome |
| title | The Skin Epilipidome in Stress, Aging, and Inflammation |
| title_full | The Skin Epilipidome in Stress, Aging, and Inflammation |
| title_fullStr | The Skin Epilipidome in Stress, Aging, and Inflammation |
| title_full_unstemmed | The Skin Epilipidome in Stress, Aging, and Inflammation |
| title_short | The Skin Epilipidome in Stress, Aging, and Inflammation |
| title_sort | skin epilipidome in stress aging and inflammation |
| topic | skin ultraviolet inflammation stress oxidized phospholipid epilipidome |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2020.607076/full |
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