ENDURAGen graft durability in α-Gal disease
Purpose: We present a case of eyelid reconstruction using ENDURAGen, a porcine-derived acellular collagen graft, complicated by dissolution of the graft in a patient recently diagnosed with α-Gal disease. Observations: A 33-year-old female status post enucleation of the left eye at age 7 struggling...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993622003838 |
| _version_ | 1811283152870572032 |
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| author | Kelly L. Ruland Maria Kirzhner |
| author_facet | Kelly L. Ruland Maria Kirzhner |
| author_sort | Kelly L. Ruland |
| collection | DOAJ |
| description | Purpose: We present a case of eyelid reconstruction using ENDURAGen, a porcine-derived acellular collagen graft, complicated by dissolution of the graft in a patient recently diagnosed with α-Gal disease. Observations: A 33-year-old female status post enucleation of the left eye at age 7 struggling with malposition of her prosthesis due to lower lid retraction and laxity underwent eyelid reconstruction with ENDURAGen. She did well post-operatively for 9 months, but then began having issues with prosthesis dislodgement and rotation. Around that time, the patient was diagnosed with α-Gal disease. Repeat eyelid reconstruction was performed, this time with an ear cartilage graft, and dissolution of the original ENDURAGen graft was confirmed. Conclusions and importance: This case highlights the need for evaluation of the durability of ENDURAGen in patients with α-Gal and for caution in choosing porcine or bovine-derived implants for tissue reconstruction in this population. |
| first_indexed | 2024-04-13T02:06:28Z |
| format | Article |
| id | doaj.art-cee969d0c0084690a5a5b0d3d09f3589 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-04-13T02:06:28Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-cee969d0c0084690a5a5b0d3d09f35892022-12-22T03:07:27ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362022-09-0127101637ENDURAGen graft durability in α-Gal diseaseKelly L. Ruland0Maria Kirzhner1Corresponding author. Department of Ophthalmology, University of Virginia, PO Box 800715 Charlottesville, VA, 22908-0715, USA.; Department of Ophthalmology, University of Virginia, Charlottesville, VA, 1300 Jefferson Park Avenue, Charlottesville, VA, 22903, USADepartment of Ophthalmology, University of Virginia, Charlottesville, VA, 1300 Jefferson Park Avenue, Charlottesville, VA, 22903, USAPurpose: We present a case of eyelid reconstruction using ENDURAGen, a porcine-derived acellular collagen graft, complicated by dissolution of the graft in a patient recently diagnosed with α-Gal disease. Observations: A 33-year-old female status post enucleation of the left eye at age 7 struggling with malposition of her prosthesis due to lower lid retraction and laxity underwent eyelid reconstruction with ENDURAGen. She did well post-operatively for 9 months, but then began having issues with prosthesis dislodgement and rotation. Around that time, the patient was diagnosed with α-Gal disease. Repeat eyelid reconstruction was performed, this time with an ear cartilage graft, and dissolution of the original ENDURAGen graft was confirmed. Conclusions and importance: This case highlights the need for evaluation of the durability of ENDURAGen in patients with α-Gal and for caution in choosing porcine or bovine-derived implants for tissue reconstruction in this population.http://www.sciencedirect.com/science/article/pii/S2451993622003838Oculoplastic surgeryEyelid reconstructionENDURAGenBiosynthetic soft tissue graftα-Gal diseaseAllergy |
| spellingShingle | Kelly L. Ruland Maria Kirzhner ENDURAGen graft durability in α-Gal disease American Journal of Ophthalmology Case Reports Oculoplastic surgery Eyelid reconstruction ENDURAGen Biosynthetic soft tissue graft α-Gal disease Allergy |
| title | ENDURAGen graft durability in α-Gal disease |
| title_full | ENDURAGen graft durability in α-Gal disease |
| title_fullStr | ENDURAGen graft durability in α-Gal disease |
| title_full_unstemmed | ENDURAGen graft durability in α-Gal disease |
| title_short | ENDURAGen graft durability in α-Gal disease |
| title_sort | enduragen graft durability in α gal disease |
| topic | Oculoplastic surgery Eyelid reconstruction ENDURAGen Biosynthetic soft tissue graft α-Gal disease Allergy |
| url | http://www.sciencedirect.com/science/article/pii/S2451993622003838 |
| work_keys_str_mv | AT kellylruland enduragengraftdurabilityinagaldisease AT mariakirzhner enduragengraftdurabilityinagaldisease |