A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT)
Parathyroid adenoma is a major clinical manifestation of primary hyperparathyroidism, which is usually diagnosed with invasive methods. In most of the cases delayed washout of radio tracer is appreciated on routine parathyroid scintigraphy. Exceptionally in some cases, early washout of tracer is see...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Clinical and Scientific Research |
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| Online Access: | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2021;volume=10;issue=2;spage=118;epage=121;aulast=Sricharan |
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| author | K B Sricharan Rayudu Amrutha Lakshmi V S Krishna Mohan Gali Sai Chandana Ranadheer Manthri Gupta Mutheeswaraiah Yootla Tekchand Kalawat |
| author_facet | K B Sricharan Rayudu Amrutha Lakshmi V S Krishna Mohan Gali Sai Chandana Ranadheer Manthri Gupta Mutheeswaraiah Yootla Tekchand Kalawat |
| author_sort | K B Sricharan |
| collection | DOAJ |
| description | Parathyroid adenoma is a major clinical manifestation of primary hyperparathyroidism, which is usually diagnosed with invasive methods. In most of the cases delayed washout of radio tracer is appreciated on routine parathyroid scintigraphy. Exceptionally in some cases, early washout of tracer is seen which results in false negative parathyroid scintigraphy due to various factors such as expression of p glycoprotein, expression of multidrug resistant protein 1, small glands and presence of chief cells. We present a the case of a patient with parathyroid adenoma showed fast tracer clearance on delayed images but anatomically localized by the additional images using single-photon emission computed tomography-computed tomography (SPECT-CT). The anatomically localized structure further characterized by histopathological examination with presence of abundant chief cells, the cause of poor tracer retention and fast clearance in delayed images. Knowledge about differential presence of chief cells and oxyphilic cells in various parathyroid adenomas must be considered by nuclear physician to avoid false negative parathyroid adenoma. |
| first_indexed | 2024-12-12T01:29:48Z |
| format | Article |
| id | doaj.art-ceeaa07393ea47b590827e42e079e78b |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-12-12T01:29:48Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-ceeaa07393ea47b590827e42e079e78b2022-12-22T00:43:01ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572021-01-0110211812110.4103/JCSR.JCSR_115_19A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT)K B SricharanRayudu Amrutha LakshmiV S Krishna MohanGali Sai ChandanaRanadheer Manthri GuptaMutheeswaraiah YootlaTekchand KalawatParathyroid adenoma is a major clinical manifestation of primary hyperparathyroidism, which is usually diagnosed with invasive methods. In most of the cases delayed washout of radio tracer is appreciated on routine parathyroid scintigraphy. Exceptionally in some cases, early washout of tracer is seen which results in false negative parathyroid scintigraphy due to various factors such as expression of p glycoprotein, expression of multidrug resistant protein 1, small glands and presence of chief cells. We present a the case of a patient with parathyroid adenoma showed fast tracer clearance on delayed images but anatomically localized by the additional images using single-photon emission computed tomography-computed tomography (SPECT-CT). The anatomically localized structure further characterized by histopathological examination with presence of abundant chief cells, the cause of poor tracer retention and fast clearance in delayed images. Knowledge about differential presence of chief cells and oxyphilic cells in various parathyroid adenomas must be considered by nuclear physician to avoid false negative parathyroid adenoma.http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2021;volume=10;issue=2;spage=118;epage=121;aulast=Sricharan99mtechnetium methoxyisobutylisonitrile (99mtc mibi) parathyroid scintigraphyearly washout parathyroid adenomaparathyroid chief cellssingle-photon emission computerized tomography-computed tomography |
| spellingShingle | K B Sricharan Rayudu Amrutha Lakshmi V S Krishna Mohan Gali Sai Chandana Ranadheer Manthri Gupta Mutheeswaraiah Yootla Tekchand Kalawat A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT) Journal of Clinical and Scientific Research 99mtechnetium methoxyisobutylisonitrile (99mtc mibi) parathyroid scintigraphy early washout parathyroid adenoma parathyroid chief cells single-photon emission computerized tomography-computed tomography |
| title | A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT) |
| title_full | A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT) |
| title_fullStr | A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT) |
| title_full_unstemmed | A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT) |
| title_short | A case of predominantly chief cell parathyroid adenoma showing early washout of 99mTc MIBI detected by single-photon emission computerized tomography-computed tomography (SPECT-CT) |
| title_sort | case of predominantly chief cell parathyroid adenoma showing early washout of 99mtc mibi detected by single photon emission computerized tomography computed tomography spect ct |
| topic | 99mtechnetium methoxyisobutylisonitrile (99mtc mibi) parathyroid scintigraphy early washout parathyroid adenoma parathyroid chief cells single-photon emission computerized tomography-computed tomography |
| url | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2021;volume=10;issue=2;spage=118;epage=121;aulast=Sricharan |
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